乌司他丁对急性百草枯中毒患者多器官保护作用.docx

急性百草枯中毒患者血清细胞因子的变化与预后相关性研究王煜【摘要】目的:探讨百草枯(paraquat, PQ) 中毒患者血清肿瘤坏死因子(TNF- α)及白细胞介素-6(IL-6 )水平变化与疾病预后的关系,以及炎症介质在 PQ 中毒发病过程中的作用。方法: 收集 2010 年1月-2014 年12月我院急诊科收治的 PQ中毒患者共 60例,分为存活组(n=18 )和死亡组(n=42 ),另选 15例健康成人作为正常对照组,采用双抗体夹心酶联免疫吸附法( ELASA )测定患者入院后 1、 3、7d血清 TNF- α及IL-6 水平;并采用急性生理学与慢性健康评分 II(APACHE II) 系统对患者进行病情严重程度的评分。比较各组患者血清 TNF- α、IL-6 水平及 APACHEII 评分的差异。结果:存活组和死亡组患者血清 TNF- α及IL-6 水平与对照组相比明显升高,差异具有统计学意义( P< );死亡组患者血清 TNF- α及 IL-6 水平高于存活组,两组相比差异具有统计学意义( P< )。 PQ中毒患者 APACHEII 评分死亡组高于存活组(P< );血清 TNF- α和IL-6 水平与 APACHEII 评分具有明显相关性。结论: TNF- α和IL-6 参与了 PQ中毒的发病过程,并与 PQ 中毒患者病情严重程度及预后有一定的相关性;可以作为早期反映病情严重程度的参考指标和 PQ中毒预后不良的预警指标。【关键词】百草枯中毒,肿瘤坏死因子-α,白细胞介素-6,APACHEII 评分, 预后 PQP by detecting serum MMP-9, TNF- α and IL-6 levels, and dynamic observation of MMP-9 and changes in inflammatory mediators and pare the survival group and death group MMP-9, TNF- α, IL-6 levels and APACHEII differences. Research MMP-9 and inflammatory mediators at the role of PQP explore PQP serum MMP-9, TNF- α, IL-6 levels and PQP prognosis. Methods : Retrospective analysis in January 2005 ~ December 2008 PQP in my Section treated patients with a total of58 cases, divided into the survival group (n=18) and death group (n= 40), selected 15 cases of healthy adults as normal control group, using double-antibody sandwich enzyme-linked immunosorbent assay (ELASA) Determination of1,3,7 days after admission in pati