中晚期贲门癌手术及术后辅助化疗的临床研究.doc

1 中晚期贲门癌手术及术后辅助化疗的临床研究作者:顾云,孙冬青,陈桂明,施乃明,高文闯【摘要】目的探讨中晚期贲门癌手术及术后辅助化疗的治疗效果。方法随机抽取 50 例单纯手术患者为单纯手术组, 50 例术后辅助化疗患者为术后化疗组, 并进行对照研究, 术后化疗组根据患者自愿原则采用丝裂霉素和 5- 氟尿嘧啶, 于术后半年内进行 1~4 次辅助化疗, 随访 5年,2 组进行疗效比较。结果单纯手术组 1、3、5 年生存率分别为 92% ( 46/50 )、 40% ( 20/50 )、 22% ( 11/50 ) ,术后化疗组 1、3、 5 年生存率分别为 88% ( 44/50 )、 68% ( 34/50 )、 36% ( 18/50 )。结论中晚期贲门癌手术及术后辅助化疗可以提高患者的远期生存率。【关键词】中晚期贲门癌;手术;术后辅助化疗 Abstract: Objective To investigate the efficiency and value of surgical treatment and postoperative adjuvant 2 chemotherapy for intermediate and advanced cardiac cancer. Methods 100 patients with intermediate or advanced cardiac cancer were randomized into two groups: surgery alone group (50 cases) and postoperative adjuvant chemotherapy group (50 cases). Patients in the postoperative chemotherapy group were given mitomycin and 5-Fu by the principle of voluntariness, while the patients recEived 1 to4 times of postoperative chemotherapy within half a year as of the operation. The efficiency and value of the treatments for the two groups during the five-year follow-ups pared. Results The survival rate within 1,3 and 5 years in the surgery alone group was 92% (46/50), 40% (20/50) and 22% (11/50), respectively, and the percentage in postoperative chemotherapy group was 88% (44/50), 68% (34/50) and 36%(18/50), respectively. Conclusion Surgical bined with postoperative chemotherapy is an effective therapy for patie