急性白血病化疗前后检测血清α1AG的意义.doc

1 急性白血病化疗前后检测血清α1拟 AG 的意义作者:李萍,张代民,王化芬,崔庆【摘要】目的探讨急性白血病(AL) 患者血清α1拟酸性糖蛋白(α1拟 AG) 的水平及其临床意义。方法选择 51 例急性白血病初治患者及 11 例复发患者,采用免疫透射比浊法测定其血清中α1拟酸性糖蛋白的含量,并与正常对照组比较。结果 AL 初治组及复发组血清α1拟 AG 水平均明显高于正常人对照组水平, 差异有非常显著性意义(t=23 . 658 , P0 . 001) ; 15 例完全缓解(CR) 患者血清α1拟 AG 水平均明显下降, 与正常对照组相比较, 差异均无显著性意义(t=0 . 776 , P0 . 05) , 与其化疗前血清α1拟 AG 水平比较, 结果差异显著(t=28 . 799 , P0 . 001) ; 急性淋巴细胞白血病(ALL) 难治组血清α1拟 AG 水平均明显高于非难治组, 差异具有显著性意义(t=16 . 167 , P0 . 001) 。急性髓细胞性白血病(AML) 难治组血清α1拟 AG 水平均高于非难治组水平,且差异均具有统计学意义(t=16 . 672 , P0 . 001) 。结论检测血清α1拟 AG 水平对于监测急性白血病的化疗效果及复发有一定临床价值。 2 【关键词】α1拟酸性糖蛋白;白血病;急性 Abstract : Objective To study serum level ofα1拟 acid glycoprotEin (α1拟 AG) in the patients with acute leukemia (AL) and its clinical A total of 51 patients with AL before treatment and 11 relapsing patients were selected. The ir serum level ofα1拟 AG was measured pared with that of normal controls. Results Serum level ofα1拟 AG was significantly higher in the patients with AL before treatment and in the relapsing patients than in the normal controls (t=, ). The serum α1拟 AG level of plete remission (CR) patients decreased significfintly, and the difference between CR group and the normal group was not significant (t=,). The serum α1拟 AG level of refractory acute lymphocyte leukemia (ALL) patients were significantly higher than that of the remission group, and the difference b