喹诺酮类不良反应与构效关系分析.doc

喹诺酮类不良反应与构效关系分析
安徽医科大学药学系学位论文
喹诺酮类结构与不良反应的关系探讨
The Exploration of Quinolones structure
and it's Adverse Reaction
指导教师姓名石静波老师
申请学位级别学士专业名称药学
提交论文日 2008-5-20
论文答辩日期 2008-5-25
二〇〇八年五月
目录
中文摘要?????????????????????????2
英文摘要???????????????????????? 2
正文???????????????????????????3
1 概述??????????????????????????3
2 喹诺酮类结构功能与特点?????????????????5
药效基团的主要功能及毒性?????????????5
药动基团的结构特点????????????????5
3 主要不良反应与功能基团的关系分析????????????6
神经系统的不良反应????????????????6
心脏毒性?????????????????????7
光敏反应?????????????????????8
对软骨和牙齿的影响????????????????9
其它不良反应???????????????????10
4 喹诺酮类合理应用????????????????????10
严格掌握用药指征?????????????????10
用药注意事项???????????????????10
配伍用药注意事项?????????????????11
5结语??????????????????????????11
6参考文献????????????????????????12
7致谢??????????????????????????13
1
喹诺酮类结构与不良反应的关系探讨
孙宁石静波
[摘要] 喹诺酮类药物是指含喹啉环系的衍生物,本文通过大量文献资料,针对喹诺酮类药物的不良反应与结构式的关系进行分析。认为C3-羧基,C4-酮基氧,C6-氟原子是基本结构基团,也是产生药理和毒理
作用的主要基团;不良反应严重程度则与N1-,C7-,C8-的侧链演变有
关,通过这些分析,提出喹诺酮类药物注意事项以及合理运用,减少不良反应的发生,提高疗效。
[关键词] 喹诺酮类;不良反应;构效关系;合理用药
The Exploration of Quinolones structure and it's Adverse Reaction
[Abstract]: Quinolones belongs to the department of central paper makes a analysis of Quinolones relationship between adverse reactions and structure through a large amount of think that C3-that Carboxyl, C4-Keto oxygen, C6-Fluorine atoms are not only the basic structural gems of Quinolones,but also the main gems which causing pharmacology and toxicology , especialy the severity of the adverse reactions has something to do with N1-C7-and side-chain-C8 the evolution. Through these analyses, the paper calls for the attention to how to use Quinolones so as to reduce the occurrence of adverse reactions, and improve the curative effect.
[Key Words]: Quinolones;Adverse Reaction;Structure-activity relationships;Rational administration
2

喹诺酮类抗菌药是人工化学合