肝功能失代偿对维库溴铵肌松时效影响.docx

上海交通大学硕士毕业论文
the liver retransplantation. Mechanomyography of the adductor pollicis
muscle with single twitch (ST; Hz) stimulation was used to monitor
neuromuscular function during anesthesia. After intravenous injection of
midazolam and fentanyl 4µg/kg, a continuous Hz single
stimulus with ms square wave and current of 50mA was delivered to
the ulnar nerve at the wrist and the evoked response of the the adductor
pollicis muscle was recorded. The twitch response was stablized for 3-5
minutes. Then propofol 1- and vecuronium were
administered intravenously. After T1 became 0, tracheal intubation and
mechanical ventilation were performed. The end-tidal carbon dioxide
tension was kept between 30 and 35mmHg . Core temperature was
measured with an oesophageal probe. Anesthesia was maintained with a
continuous intravenous infusion of propofol and boluses of fentanyl
IV as required. The onset of vecuronium,duration of action,the
time of T1 recovery to 10% of baseline were observed and recorded. The
condition of tracheal intubation was judged. When T1 returned to 10% of
baseline, vecuronium was infused continuously at a initial rate of
2µg·kg-1·min-1 to maintain T1 at 5%-10% of baseline by adjusting the
infusion rate. The vecuronium consumption in every thirty minutes was
recorded and the average infusion rate in y minutes was calculated.
Results

The onset of vecuronium were ± in group 1,
and ± in group 2 respectively with statistically significant
8
上海交通大学硕士毕业论文
difference(P < ). Duration of action of first dose of vecuronium were
± in group 1 and ± in group 2(P > ).
Times of T1 recovery to 10% were ± in group 1,and
± in group 2(P > ). The first thirty-minute
consumption of vecuronium in group 1 and group 2 were ±
and ±( P< ); the second were ± ,
± , and the th