免疫球蛋白(Ig)PPT课件.ppt

Immunoglobulin , Ig
NOBEL PRIZES FOR ANTIBODY RESEARCH
Ig gene rearrangement
Tonegawa
1987
Monoclonal Ab
Koler,Milstein & Jerne
1984
Radioimmunoassay
Yalow
1977
Chemical structure of Ab
Edelman
& Poter
1972
antitoxin
Ehrlich & Metchnikoff
1908
Serum therapy
von Bering
1901
1890:
von Behring and Kitasato
-ANTIBODIES
in the serum of inated individual bind to pathogens
Emil von Behring 1854 - 1917, Nobel Prize in 1901 for demonstrating that circulating antitoxins against diphtheria and tetanus toxins conferred immunity.
Discovery of Ab
Emil von Behring and Shibasaburo Kitasato took serum from animals infected with diphtheria and injected it into healthy animals. When these animals were later inoculated with diphtheria they were found to be resistant to infection. We now know this method of conferring infection resistance as "passive immunity". This first demonstration of defense against infection was revealed and described as mediated by "antitoxin". It was clear to Behring and Kitasato that the antitoxin was specific only for diphtheria, it did not confer any defense against other forms of infection. We now know this antitoxin to be antibodies produced specifically against the diphtheria microbe.
Albumin
-globin -globin -globin
正常血清蛋白电泳图
Immune sera
Normal sera
Ⅰ. Basic Immunoglobulin Structure
Ig的基本结构
Ⅰ
Ⅰ
Ig的基本结构(IgG )
四肽链结构
功能区
绞链区
接合链
分泌片
酶解片段