肾形n-HPA66腰椎间融合器猪腰椎TLIF手术的体外生物力学研究.docx

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肾形n-HPA66腰椎间融合器猪腰椎TLIF手术的体外生物力学研究
摘要：
背景：腰椎间融合手术是治疗椎间盘突出、骨刺、髓核突出、脊柱关节病等疾病的重要方法。肾形n-HPA66腰椎间融合器是一种新型的腰椎间融合器，其在体外实验的生物力学研究还较少。
目的：本研究旨在评价不同材质的椎间融合器和不同植入角度对椎间融合的影响以及肾形n-HPA66腰椎间融合器的性能。
方法：选取6只猪腰椎，将其分为三组，分别植入肾形n-HPA66腰椎间融合器、PEEK腰椎间融合器和钛合金腰椎间融合器。同时评估不同植入角度对椎间融合器的影响，分别为35°和55°。测定不同条件下椎间融合器承载25N力和200N力的结果，并记录植入组件的破坏负荷，以及在压缩负载下融合体的生物力学性能， mm压缩和90°扭曲运动。
结果：大多数测定结果表明，肾形n-HPA66腰椎间融合器具有较好的力学性能，特别是具有良好的融合性能和耐力性能。植入角度提高（55°）有助于提高椎间融合器的力学性能，尤其是融合器的扭转强度和破坏负荷。相比之下，PEEK腰椎间融合器和钛合金腰椎间融合器发现扭曲补偿和破坏负荷均较差。
结论：本研究表明，肾形n-HPA66腰椎间融合器的力学性能良好。植入角度可以影响融合器的力学性能，较高的植入角度可以提高其力学性能，但在操作中需要注意。本研究也为选择合适材质的椎间融合器提供了一定的参考。
关键词： 腰椎间融合器，生物力学，肾形n-HPA66，植入角度，承载力
Introduction:
Lumbar interbody fusion surgery is an important method for treating diseases such as intervertebral disc herniation, osteophyte, nucleus pulposus protrusion, and spinal joint disease. The renal-shaped n-HPA66 lumbar interbody fusion device is a new type of lumbar interbody fusion device, and its biomechanical study in in vitro experiments is still relatively rare.
Objective: This study aims to evaluate the influence of different materials of interbody fusion devices and different implantation angles on interbody fusion and the performance of the renal-shaped n-HPA66 lumbar interbody fusion device.
Methods: Six porcine lumbar vertebrae were selected and divided into three groups, implanted with renal-shaped n-HPA66 lumbar interbody fusion device, PEEK lumbar interbody fusion device, and titanium alloy lumbar interbody fusion device, respectively. At the same time, the effect of different implantation angles on the interbody fusion device was evaluated, which were 35° and 55°, respectively. The results of measuring the load-bearing capacity of the interbody fusion device under 25N force and 200N force were determined, and the failure load of the implanted component was recorded, as well as the biomechanical performance of the fusion body under compressive load, including mm compression and 90° twisting motion.
Results: Most measurement results show that the renal-shaped n-HPA66 lumbar interbody fusion device has good mechanical performance, especially good fusion and endurance capabilities. An increased implantation angle (55°) helps to improve the mechanical performance of the interbody fusion device, particularly its torsion strength and failure load. In contrast, PEEK lumbar interbody fusion device and titanium alloy lumbar interbody fusion device have poor twisting compensation and failure load.
Conclusion: This study shows that the renal-shaped n-HPA66 lumbar interbody fusion device has good mechanical performance. The implantation angle can affect the mechanical performance of the fusion device, and a higher implantation angle can improve its mechanical performance, but attention should be paid during operation. This study also provides some reference for selecting appropriate materials for interbody fusion devices.
Key words: Lumbar interbody fusion device, Biomechanics, Renal-shaped n-HPA66, Implantation angle, Load-bearing capacity.