0000000d_中华苦荬菜根部化学成分研究.doc

中华苦荬菜根部化学成分研究
郭华强,吴盼昭,杨雪梅,张树军(齐齐哈尔大学化学化工学院,黑龙江齐齐哈尔 161006)
摘要:目的研究中华苦荬菜(Ixeris chinensis (Thunb.) Nakai) 根部化学成分。方法利用硅胶柱色谱和HPLC进行分离纯化,根据理化性质和波谱数据进行结构鉴定。结果得到14个愈创木烷型倍半萜内酯类化合物。结论化合物3、6、7、10、11、12、13为新,命名为Chinensiolide F、Chinensiolide G、Chinensiolide H、Chinensiolide I、Chinensiolide J、Chinensiolide K、Chinensiolide L,化合物4、5、8为首次从中华苦荬菜中分离得到。
关键词:中华苦荬菜;菊科;倍半萜;中华内酯
Chemical constituents isolated from the root of Ixeris chinensis (Thunb.) Nakai
GUO Hua-qiang, WU Pan-zhao, YANG Xue-mei, ZHANG Shu-jun (College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, China)
ABSTRACT: OBJECTIVE To study the chemical constituents of the root of Ixeris chinensis (Thunb.) Nakai. METHODS Chemical constituents were isolated by column chromatography and purified by HPLC, and identified by spectral datas. RESULTS Fourteen guaiane type sesquiterpene lactones were isolated and identified respectively pounds 3、6、7、10、11、12、13 are isolated from natural products for the first time and named Chinensiolide F、Chinensiolide G、Chinensiolide H、Chinensiolide I、Chinensiolide J、Chinensiolide K、Chinensiolide L respectively. Compounds 4、5、8 are isolated from Ixeris chinensis (Thunb.) Nakai for the first time.
KEY WORDS: Ixeris chinensis; Composite; sesquiterpene; chinensiolide
中华苦荬菜又名丝叶苦菜,山苦菜,系菊科被子植物,一至二年生或多年生草本,叶或茎被折断后有白色乳状物流出,全草呈苦味。具有清热、解毒、消炎、凉血、止痛、消肿、抗肿瘤等功效。苦菜的根、茎、叶、花、果均可入药,用于治疗无名肿痛、腹腔