氨磷汀配合紫杉醇和顺铂同步放化疗治疗局部晚期非小细胞肺癌的临.doc

氨磷汀配合紫杉醇和顺铂同步放化疗治疗局部晚期非小细胞肺癌的临.doc氨磷汀配合紫杉醇和顺铂同步放化疗治疗局部晚期非小细胞肺癌的临
翁向群庄聪文程先进杨胜生曾志勇张哲明姜洪
【摘要】目的观察氨磷汀联合同步放化疗治疗局部晚期非小细胞肺癌的疗效及对正常组织的保护作用与安全性。方法 60例Ⅲa~Ⅲb期的非小细胞肺癌,随机分为两组,对照组(n=30例):同步放化疗,未使用氨磷汀预处理;治疗组(n=30例):同步放化疗,使用氨磷汀预处理(300 mg/m2·d -1)。化疗方案为紫杉醇(60 mg/m2)联合顺铂(30 mg/m2),放疗应用6MV X线,2 Gy/次,5次/周,总剂量50~60 Gy。治疗期间评价血细胞变化、食管炎、急性肺毒性及近期疗效。结果两组患者的临床特征比较无显著差异,治疗组食管炎的发病率明显低于对照组(43%和83%,P<),治疗组急性肺毒性的发病率明显低于对照组(27%和54%,P<),对照组的有效率(CR+PR)%,%,二者无统计学意义(P>)。结论氨磷汀能有效减少局部晚期非小细胞肺癌的同步放化疗的急性毒副作用,且不降低抗肿瘤效应。
【关键词】同步放化疗;非小细胞肺癌;氨磷汀;毒副作用;细胞保护作用
Abstract: Objective To evaluate the efficacies of radiochemotherapy (RCT) alone and RCT plus pretreatment ifostine on local advanced non?small?cell lung cancer (NSCLC) and their side effects. Methods Sixty patients ized into control group (RCT alone, n=30) and trial group [RCT plus pretreatment of amifostine (300 mg/m2/d), n=30]. RCT included paclitaxel (60 mg/m2) plus cisplatin (30mg/m2) once per ent efficacy ifostine than in those taking RCT alone (43% vs. 83%, P<). The incidence of acute pulmonary toxicity ifostine (27% vs. 53%, P<). The rates of total response (plete plus partial responses) to the treatment ifostine is effective on reducing the incidence of acute toxicities associated ising antitumor efficacy.
Key otherapy; non?small?cell lung cancer; amifostine; side effect; cytoprotectant
2007年12月第35卷第6期临床军医杂志(Clin J Med Offic)肺癌是最常见的恶性肿瘤,大