活性因子负反馈降低癌细胞中谷胱甘肽含量实验摘录.doc

3. The Use of a Whey Protein Concentrate in the Treatment of Patients with Metastatic Carcinoma: A Phase I-II Clinical Study
Renee S. Kennedy1, e P. Konok1, Gustavo Bounous2, Sylvain Baruchel3 and Timothy . Lee4
1Department of Surgery, Dalhousie University, Halifax, Nova Scotia, 2Department of Surgery, McGill University, Montreal Quebec,3Department of Pediatrics and Oncology, McGill University, Montreal, Quebec, 4Department of Immunology and Microbiology, Dalhousie University, Halifax, Nova Scotia, Canada
Anticancer RESEARCH 15: 2643-2650, 1995
Abstract: Glutathione (GSH) concentration is high in most tumor cells and this may be an important factor in resistance to chemotherapy.  Previous in-vitro and animal experiments have shown a differential response of tumor versus normal cells to various cysteine delivery systems.  More specifically, an in-vitro assay showed that at concentrations that induce GSH synthesis in normal human cells, a specially prepared whey protein concentrate, ABD活性因子, caused GSH depletion and inhibition of proliferation in human breast cancer cells.  On the basis of this information five patients with metastatic carcinoma of the breast, one of the pancreas and one of the liver were fed 30 grams of this whey protein concentrate daily for six months.  In six patients the blood lymphocyte GSH levels were substantially above normal at the outset, reflec