VEGF及其抗体对兔屈肌腱愈合作用的实验研究.pdf

第三军医大学
硕士学位论文
VEGF及其抗体对兔屈肌腱愈合作用的实验研究
姓名:徐红立
申请学位级别:硕士
专业:外科学(骨科)
指导教师:王爱民
20040501
第三军医大学硕士学位论文
英文缩写一览表

英文缩写英文全称中文全称
bFGF basic fibroblast growth factor 碱性成纤维细胞生长因子
plementarity-determining region 互补决定区
DAB diaminobenzidine 3,3-二氨基苯联胺
d day 天
ECM extracellular matrix 细胞外基质
EDTA-Na2 etraacetate disodium 乙二胺四乙酸二钠
FGFs fibroblast growth factors 成纤维细胞生长因子
flk-1 fetal liver kinase 胎肝激酶
flt-1 fms-like tyrosine kinase fms-样酪氨酸激酶
HA hyaluranic acid 透明质酸
HE hematoxylin and esoin 苏木素伊红染色
IOD integrated optical density 积分光密度
KDR kinase insert domain-containing receptor 激酶插入区受体
min minute 分钟
PBS phosphate buffered saline 磷酸盐缓冲液
PDGF platelet-derived growth factor 血小板源性生长因子
PFA paraformaldehyde 多聚甲醛
rhuMabVEGF binant monoclonal antibody to VEGF 重组人源性 VEGF 单克隆
抗体
TGF- 1 transforming growth factor beta1 转化生长因子 1
VAS vasculotropin 促血管因子
VEGF vascular endothelial growth factor 血管内皮生长因子
VEGFR-1 vascular endothelial growth factor receptor 1 血管内皮生长因子受体 1
VEGFR-2 vascular endothelial growth factor receptor 2 血管内皮生长因子受体 2
VPF vascular permeability factor 血管通透因子

1
第三军医大学硕士学位论文
Effects of VEGF and Its Neutralizing Antibody on Flexor
Tendon Healing: An Experimental Study in Rabbits

Abstract

It,s mon injury of tendon broken and defection in hand surgery. Tendon
adhesions, which happened after operative repair or transplantation, restrict tendon to glide
and severely prevent the rehabilitation of hand function. Tenolysis is needed subsequently
in many times. It has been shown that many growth factors play important role in tendon
repair regulation in recent researches. In tendon healing process, tenocytes proliferate and
differentiate, synthesize and excrete extracellular matrix such as collegan and fibronectin
with the effect of intrinsic growth factors. The growth factors is in action mainly through
paracrine or autocrine in local.
Intrinsic and extrinsic healing are both existed in tendon healing. the