米诺环素软膏与甲硝唑凝胶治疗老年患者慢性牙周炎疗效比较 【摘要】目的比较盐酸米诺环素与甲硝唑治疗老年慢性牙周炎的临床效果。方法选择50例老年慢性牙周炎的患者,共100颗牙。全口洁治和根面平整后,以患者一侧患牙局部应用盐酸米诺环素软膏为实验组,对侧同名患牙局部应用甲硝唑凝胶作为对照组。每周置药1次,4 w为一个疗程。于基线、基线后5、9 w检测菌斑指数(PLI)、龈沟出血指数(SBI)、探诊深度(PD)。结果两组临床指标均较基线有明显改善,PLI实验组优于对照组,差异有显著性(P<)。结论牙周袋内应用米诺环素软膏配合牙周基础治疗,能够有效地改善牙周炎症状,且效果优于甲硝唑凝胶组。 【关键词】盐酸米诺环素甲硝唑周炎局部缓释 Abstract:Objective pare the clinical effects of minocycline hydrochloride and metronidazole gel treating gerontal chronic periodontitis. Methods 50 gerontal patients with chronic periodontitis with a total of 100 teeth were included in the study. After scaling and root planting, one side of each tooth of the patients was assigned as an experimental group and treated with minocycline hydrochloride. The contra lateral tooth of the patients was assigned as a control group and treated with metronidazole gel. All the treatments were applied once a week, and four times as a treatment period. For both groups, the following indexes were recorded at the baseline ,5 weeks, and 9 weeks after the treatment: plaque index (PLI), sulcus bleeding index (SBI), and probing depth (PD). Results Both groups showed significant improvement in their examined indexes, and the PLI scores were significantly lower in the experimental group than those in the control group. Conclusions Local drug delivery of minocycline hydrochloride can effectively treat chronic periodontitis and is m
