溶血三项与新生儿溶血病的关系.doc

溶血三项与新生儿溶血病的关系
doi:.1007-
摘要目的:了解溶血三项试验对新生儿溶血病的诊断及临床价值。方法:严格按照交叉配血实验要求进行操作。结果:279例新生儿溶血病检测,其中O型血63例(23%),8例阳性(3%),121例阴性(43%),87例疑似(31%)。结论:溶血三项试验对新生儿溶血病具有较为准确的诊断意义。
关键词血型新生儿溶血病
The relationship of three hemolysis and hemolytic disease of newborn
Guo Buqing
Dpartment of Laboratory of Jiaozuo Maternity and child Hospital in Henan Province,454000
Abstract Objective:To hemolysis three trials for the diagnosis of hemolytic disease of the newborn and clinical :in strict accordance with the requirements of cross-matching blood test :279 cases of hemolytic disease of newborns detected 63 cases in which blood type O,accounting for 23%;eight cases positive,accounting for 3%;121 cases negative,accounting for 43%;87 cases suspected,accounting for 31%.Conclusion:hemolysis three trials with a more accurate diagnosis of hemolytic disease of the newborn,is worthy of promoting.
Key words Blood type;Newborn;Hemolytic disease
新生儿同种免疫性溶血症简称新生儿溶血症(HDN),系因母子血型不合,胎儿血型抗原免疫母体后产生的与遗传有关的疾病。国内以ABO血型不合最常见,约占80%以上,Rh血型(D)较常见,E、C,或e次之,占15%左右,MN血型偶见。Duffy、Kell(K k)、Lufheran及Kidd血型也可引起,但罕见。因母亲的子宫壁和胎盘常有缺陷,母体血型常为O型,胎儿常为A或B型,胎儿的红细胞进入母体内,产生同族血型IgG型不全抗体,因抗体分子量小,容易通过胎盘进入胎儿血循环,破坏胎儿红细胞,发生溶血。新生儿出生后黄疸进行性加重,苍白,肝、脾肿大,常合并感染,当血清非结合型胆红素增多超过205μmol/L时,发生高胆红素血症,容易损害脑基底节、颅神经核和内耳细胞,即称核黄疸,可引起严重的后遗症甚至导致大脑瘫痪。
资料与方法
住院治疗新生儿279例,其表现均为高胆红素血症。其母亲血型未知。
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