冠心病英文版.ppt

冠心病英文版,冠心病能治愈吗,冠心病吃什么药最有效,冠心病,冠心病严重吗,冠心病最佳治疗方法,冠心病是怎么引起的,得了冠心病能活几年,冠心病的治疗药物,冠心病早期有8症状Atherosclerosis
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Coronary heart diseases
Zhengzhou University, First affiliated Hospital
Dept. of Cardiology
Haiyu Li, .
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Cardiovascular Diseases
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Atherosclerosis
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leading cause of death and mon location:
Coronary circulation: Proximal left anterior descending coronary artery(LAD)
Proximal portion of renal arteries
Extracranial circulation to the brain
Carotid bifurcation
Atherosclerosis
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Coronary heart disease
atherosclerosis
Coronary stenosis
coronary spasm
Myocardial ischemia, anoxaemia
Coronary heart disease, CHD
Ischemic heart disease
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Atherosclerosis
Stable angina pectoris(SAP)
Acute coronary syndrome
Unstable angina(UAP) and non-STEMI
(UA/NSTEMI)
ST elevation myocardial infarction(STEMI)
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Three fundamental biological processes of atherosclerosis
Accumulation of intimal cells:
smooth muscle cells
Macrophages
T-lymphocytes
Proliferated connective tissue matrix :
collagen
elastic fibers
proteoglycans
3. Accumulation of lipid:
cholesterol esters
free cholesterol
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Hypothesis of lipoprotein infiltration
Aggregation of platelets and thrombosis
Clonal theory
the response-to-injury hypothesis
Atherosclerosis-Hypothesis
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Response-to-injury
Atherosclerosis: hypothesis
High blood pressure,bacterium,virus,toxin,ox-LDL,
immune factor,vasoactive substance
endothelium damage and dysfunction
(vasoactive substance, adhesion and aggregation of monocytes-foam cell, platelets)
Lipidosis, growth factor, proliferation of smooth mucle cells, collagen, lipolytic enzyme,
atherosclerosis
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Pathology and pathophysiology
Fatty steak
Fibrous plicated lesion
At