医学论文壁报模.ppt

Should We Achieve the Target Doses of Beta-blockers
in Chronic Heart Failure Patients with Adequate Heart Rate Control?
Krit Leemasawat, MD; Arintaya Phrommintikul, MD; Rungsrit Kanjanavanit, MD; Wanwarang Wongcharoen, MD;
Kan Okonogi, MD; Lalita Yongsmith, MD; Sirilak Yooprasert, MD; and Apichard Sukonthasarn, MD
Faculty of Medicine, Chiang Mai University, Thailand
Purpose
Recent studies indicated that heart rate was an important target for chronic heart failure treatment, whereas the importance of doses of beta-blockers was still uncertain. We conducted a retrospective study to determine the survival prognosis of achieving the target doses of beta-blockers in chronic heart failure patients with adequate heart rate control
Methods
We screened for symptomatic chronic heart failure patients with reduced left
ventricular ejection fraction (<) (HFrEF) and newly initiated beta-blocker
treatment (bisoprolol, carvedilol, metoprolol tartrate, or nebivolol) with at least 1 year follow-up in Maharaj Nakorn Chiang Mai Hospital between the year 2000 and 2010. Among 3,754 HFrEF patients, 325 patients were eligible and were classified into 4 groups, according to heart rate control (<70 vs. ≥70 beats per minute) and target beta-blocker dose (achieved vs. not achieved) (Figure 1). The endpoint of the study was all-cause mortality.
Results
Baseline heart rate was similar in all groups.