自噬与细胞代谢及疾病关系的研究进展.pdf

第23卷第10期生命科学 Vol. 23, No. 10
2011年10月 Chinese Bulletin of Life Sciences Oct., 2011
文章编号:1004-0374(2011)10-0980-07
自噬与细胞代谢及疾病关系的研究进展
李杰1,2*,路海3,李妮娜2
(1 济宁医学院行为医学实验室,山东省行为医学重点实验室,济宁 272067;2 济宁医学院
精神卫生学院,济宁 272067;3 济宁医学院神经生物学研究所,济宁 272067)
摘要:自噬是以细胞质空泡化为特征的依赖于溶酶体的一种降解途径,是真核细胞特有的普遍生命现象。
自噬利用溶酶体降解自身损伤的细胞质和细胞器,降解产物可用于能量生成、新的蛋白质和质膜的合成,
以供细胞代谢和老化损伤细胞成分的更新,维持细胞存活、分化、发育和内环境稳态。自噬广泛参与多种
生理和病理过程。对自噬与细胞代谢及疾病发生的关系作一概述。
关键词:自噬;代谢;肿瘤;神经退行性疾病;肌病
中图分类号:Q291 文献标志码:A
Research progress in autophagy and its relations to metabolism and diseases
LI Jie1,2*, LU Hai3, LI Ni-Na2
(1 Key Laboratory of Behavior Medicine, Shandong Province and Jining Medical University, Jining 272067, China;
2 School of Mental Health, Jining Medical University, Jining 272067, China; 3 Institute of Neurobiology, Jining
Medical University, Jining 272067, China)
Abstract: Autophagy widely exists in the eukaryotic cells characteristically. It serves as a vacuolar process of cyto-
plasmic degradation by lysosomes. Cells may exploit autophagy as a means to maintain survival, differentiation, de-
velopment and cellular homeostasis. The anelles and protein aggregates are consumed in lysosomes, and
the resulting breakdown products are subsequently used for generating energy, inputting to cell metabolism and re-
placing outdated or damaged ponents with fresh ones. Autophagy exists widely i