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StemCellsandDiabetes-HowardHughesMedicalInstitute：干细胞与糖尿病-霍华德休斯医学研究所.ppt

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,%,?plicationsincludeblindness,stroke,kidneyfailure,heartdisease,poorcirculation,andamputationType1Diabetesjuvenile-onsettypicallyaffectschildrenandyoungadultsimmunesystemattacksanddestroysbetacells(βcells)umulatesinthebloodType2Diabetesadult-onsetdiabetestypicallyaffectsolder,sedentary,andoverweightindividualswithafamilyhistoryofdiabetesbodycannotuseinsulineffectivelyduetoinsulinresistance,umulatesinthebloodRoleofPancreasinDiabetesWhatisinsulin?peptidehormonesynthesizedwithintheβcellsoftheisletsofLangerhanslocatedinthepancreasaffectsmetabolismandotherbodyfunctionscausescellsintheliver,muscle,andfattissuetotakeupglucosefromthebloodstreamQuestion:IntypeIdiabetics,isitpossibletogetcellstoproduceinsulin?twopossiblesourcesofcellsexistingcellsadultstemcellsWhatareadultstemcells?Theyare:urindifferentiatedtissueabletomakeidenticalcopiesofthemselvesabletoyieldspecializedcelltypesofthetissuefromwhichtheyoriginateddonotreplicateindefinitelyinculture

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