神经生长因子联合神经干细胞移植治疗大鼠脊髓损伤神经生长移植受大鼠生长神经受.doc

神经生长因子联合神经干细胞移植治疗大鼠脊髓损伤★
范广明1,张文彬2,张赛2,王丽君3
Nerve growth bined with neural stem cell transplantation for treating spinal cord injury in rats
Fan Guang-ming1, Zhang Wen-bin2, Zhang Sai2, Wang Li-jun3
1Tianjin Medical University, Tianjin 300070, China; 2Affiliated Hospital of Medical College of Chinese People’s Armed Police Force, Tianjin 300162, China; 3First People’s Hospital, Lingyuan 122500, Liaoning Province, China
Fan Guang-ming★, Studying for master’s degree, Attending physician, Tianjin Medical University, Tianjin 300070, China
******@163.
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Correspondence to: Zhang Sai, Doctor, Doctoral supervisor, Chief physician, Affiliated Hospital of Medical College of Chinese People’s Armed Police Force, Tianjin 300162, China
zhangsai718@
Received: 2010-01-06 Accepted: 2010-02-27
Abstract
BACKGROUND: The effects of simple neural stem cell (NSC) transplantation on repair of damaged spinal cord are not ideal. Previous studies have shown that nerve growth factor (NGF) has both effects of neuron nutrition and process growth promotion, can effectively contribute to the recovery of neurofunction following spinal cord injury (SCI).
OBJECTIVE: To investigate the effect of neural stem cell bined with NGF application on the recovery of motor function of rats with SCI.
METHODS: A total of 42 Sprague Dawley rats were used to establish SPI models, and then divided randomly