盐酸二甲双胍渗透泵制剂的制备和释药因素的研究.pdf

安徽医药 AnhuiMedicalandPharmaceuticalJournal 2013Sep;17(9) ·1477·
盐酸二甲双胍渗透泵制剂的制备和释药因素的研究
刘羽1,翟光喜1,周国勤2
(,山东济南 250012;,安徽省缓控释工程技术中心,安徽合肥 230022)
摘要:目的探索一种盐酸二甲双胍微孔型渗透泵控释片的制备方法并研究其释药行为的影响因素。方法以聚醋酸乙烯酯
水分散体为控释材料制备盐酸二甲双胍渗透泵控释片,考察增塑剂、致孔剂、溶出介质等因素对药物溶出的影响。结果以聚
醋酸乙烯酯水分散体包衣制得盐酸二甲双胍渗透泵控释片的可实现稳定的零级释放。结论聚醋酸乙烯酯可用于制备微孔型
渗透泵制剂,该制备方案有望为渗透泵制剂的研究提供一种新的选择。
关键词:盐酸二甲双胍;渗透泵;聚醋酸乙烯酯
Preparationofmetforminhydrochlorideosmoticpump
controlledreleasetablets
LIUYu1,ZHAIGuangxi1,ZHOUGuoqin2
(,Jinan,Shandong 250012,China;,Anhuisustained/Controlled
ReleaseEngineeringandTechnologicalResearchCenter,Hefei,Anhui 230022,China)
Abstract:Objective Topreparetheosmoticpumpcontrolledreleasetablets(OPT)andtoinvestigatethefactorsinfluencingrelease
Metforminhydrochlorideosmoticpumpcontrolledreleasetablets
,poreformerandthedissolutionmedium
Thedissolutioncurveswerestudied,ThedrugwasreleasedfromMetforminhydrochlorideOPTatthecontrolled
.
Keywords:metforminhydrochloride;osmoticpump;polyvinylacetate
在控释制剂中,口服渗透泵最理想,它可避免普通口服制微孔型渗透泵(microporousosmoticpump,MPOP)[2]采