肝癌复发和转移的新理念.doc

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肝癌复发和转移的新理念
樊嘉史颖弘
啪钟r FAN Jia,Sill h,lg一胁几g. Research Institute of Liver


Cancer,Zhongshan Hospital,Fndan University,Shanghai

on recurrence and metastasis of liver

1肝癌复发和转移的来源
肝癌的复发可以是肝内转移或者是新发肿瘤。
遗传学的研究结果认为,在复发的肝癌中约60%~
Corresponding author:FAN
Jia,Entail:******@
70%为肝内转移,约30%~40%为新发肿瘤。而且
【Abstract】
Cancer metastasis is
considered
as
tom.
肝内转移多在术后2年内出现,新发肿瘤通常在手
of molecular signal transduction recurrence and
metastasis are major obstacles for long-term survival of liver
术2年后被发现。无论肝癌发生肝外还是肝内转
移,确定肝转移癌来源及转移行为发生的时间是其
cancer

the prognosis after recurrence
and
中的关键。我所的一项肝癌基因表达谱的研究结果
metastasis is dismal,the advancement of molecular researches of
metastasis of liver cancer seems promising。In studies of origins
of
spending metastatic liver cancer cells share similar gene signa-
ture,which indicates that genes favoring metastasis progression
are initiated in the primary metastasis of liver cancer
have
metastatic potential of liver ,a variety of
studies demonstrate that the tumor microenvironment instead of
表明,肝癌原发癌与肝内转移癌或门静脉内播散癌
栓的基因表达谱非常相似,是否发生转移的肝癌患
者的基因表达谱有很大的差异,说明肝癌的转移潜
能是具有细胞特异性的,可能在早期原发癌较小阶
段即可获得¨1。
从肿瘤转移发生的时间来看,有线性和平行两种
模式M J。线性模式强调肿瘤细胞的恶性程度随着肿
瘤的进展逐渐增强,患者多在病程的晚期发生转移,
tumor ceHs plays
more important role in liver