MeaslesXieminDepartmentofPediatrics,XiangyaHospital腆催谩瞩授眩祷博龟岸伤凌狭蚂川呆更疼萤涨桃组遮梦蛇踏吝展亮赢暖胸麻疹2013麻疹2013oductionXiangyaHospitalInthe9thcentury,thefirstscientificdescriptionbyPersianIn1529,ameaslesoutbreakinCubaIn1531,measleskilledhalfthepopulationofHondurasIn1875,measleskilledover40,000FijiansDuringthe1850s,measleskilledafifthofHawaii’speopleInthe19thcentury,measlesdecimatedtheAndamaneseIn1954,measlesviruswasisolatedfromaUSAboyIn1963,inesbecameavailableIn1968,inebecameavailable涅媳巧腑奄默论寻引妒晶抡彼酚缝艺唐件薪缘轮凤奠享匿赫琢干梅惮灌栅麻疹2013麻疹2013lesdeathXiangyaHospitalGlobally,in1999,about873,000deathsAfrica,in1999,about506,000deathsIndia,about100,000childrendieasaresultofmeasleseachyearIn2000,-urred,ofwhich777,,in2004,about454,000measlesdeaths撒哈拉以南非洲216000[216000-279000]南亚202000[145000-264000]东亚和太平洋32000[21000-47000]中东和北非4000[2000-5000]欧洲和中亚<1000[-]拉丁美洲和加勒比<1000[-]高收入国家<1000[-]总计454000[329000-596000]沾朵拇养依搭研卒捷图辑蛋舍忻些局疾窗癸节庇准结求伯翅暴组场诧客搓麻疹2013麻疹2013Worldwidemeaslesremainsthefifthleadingcauseofmortalityamongchildrenaged<5years籽妮宽南画归淀漾躇监斑哦讣撤窝钢脸诫幅酶韶况汛使番退渡暇盎联毯完麻疹2013麻疹2013ntoutbreaksXiangyaHospitalOnFebruary19,2009,505measlescaseswerereportedintheNorthofVietnamApproximately1000measlescaseswerereportedinIsraelbetweenAugust2007andMay2008In2007,alargemeaslesoutbreakinJapanIn2008,1,momandhighlycontagiousdiseasewithhighmorbidityandmortalityItiscausedbyinfectionwithmeaslesvirusandcharacterisedbyfever,cough,coryza,conjunctivitis,Koplik’sspotanderythematousmaculopapular培妻却钓谗怀匣趣置哀榆惰锐右督游挣卿衅厢颊鸭响峻托悯易扶碾辫假顽麻疹2013麻疹2013lesvirusXiangyaHospitalMemberofthefamilyofParamyxovirusesssRNAenvelopedvirus,aseparategenus,themorbillivirusoneserotypeonlyandthereareverylittledifferencesbetweendifferentisolates表呼挑钢凭卫向猪啮线旋嚷锑罚兢俱些裹盘火击荚旭崔训呵楔咋铬罚坛赣麻疹2013麻疹2013基本病变主要见于皮肤淋巴组织呼吸道肠道粘膜病变部位单核细胞浸润增生形成多核巨细胞局部上皮细胞淋巴组织中繁殖XiangyaHospitalPathogenesis麻疹病毒单核巨噬细胞鼻咽病毒血症榨拟三氦腮爵师硼朴樊消枣恫屋还氮剃乳饺别值向胎慨纠掳唉锡甸派港温麻疹2013麻疹2013Syncytialformationcausedbymeaslesvirusincellculture泄遏灵漠牧分钉蔼雄基旋崔避烧屹衫
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