InnateImmuneSystemmonocytemacrophagebacteriaThemostancientdefensePhysical&,:物理、化学、微生物血-脑屏障、血-胸腺屏障血-胎屏障、气-血屏障单核-巨噬细胞、中性粒细胞、树突状细胞、γδT细胞、NK细胞、NKT细胞、B1细胞、肥大细胞、嗜碱性粒细胞、嗜酸性粒细胞、nuocyte等。抗菌肽、溶菌酶、急性期蛋白、补体、细胞因子和黏附分子、1、固有免疫屏障(1)TheEpithelialLayer:TheinitialbarriertoinfectionOuterbodysurfaceKeratinbarrierEpithelialcellsheddingDrynessepidermiswithkeratinPhysical(mechanical)defenseofskinInnerbodysurfacesMucusViscousProtectsunderlyingcellsContainsantimicrobialfactorsLysozymeConstantfluidflowTearsSalivaIntestinalperistalticUrineproductionandurinationVaginalsecretionsMucociliaryclearanceEpithelialcellsheddingPhysical(mechanical)anismsSebum,unsaturatedfattyacids“antimicrobiallipids”LowpHSkin(pH3-5)Stomach(–3)Vagina(pH3–5)Urine(pH6)*ChemicaldefenseTLRMicrobialProducts(LPS,PG,etc)AntimicrobialPeptidesCytokinesExpresstoll-likereceptorsthatrecognizespecificPAMPProduceantimicrobialpeptides(AMP):killmicrobesSecretepro-inflammatorycytokines:alertthehostImmunefunctionofepithelialcells
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