肝郁脾虚抑郁症研究进展.pdf

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146 环球中医药 2014 年 2 月第 7 卷第 2 期 Global Traditional Chinese Medicine February 2014 Vol. 7 No. 2
·综述·
肝郁脾虚抑郁症研究进展
董洪坦韩刚朱晓晨郭蓉娟
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【摘要】肝郁脾虚证是抑郁症常见证型之一常由肝气郁结证转化而来。目前对于抑郁症肝
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郁脾虚证的基础研究一般认为肝郁脾虚时机体存在神经—内分泌—免疫系统失调、脑肠轴异
常、脑电生理功能紊乱。抑郁症肝郁脾虚证临床治疗的效应机制可能与神经—内分泌—免疫网络、
信号通路、基因表达关系密切。该文将近十年有关抑郁症肝郁脾虚证临床流行病学调查、证候标准
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化研究、病理生理学基础、临床效应及效应机制方面的研究成果及文献进行综述并对研究中存在
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的一些问题进行讨论提出今后的研究思路与建议。
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【关键词】抑郁症肝郁脾虚综述
【中图分类号】 R277. 7 【文献标识码】 A doi: 10. 3969 /j. issn. 1674-1749. 2014. 02. 022
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Progress on depression due to liver stagnation and spleen deficiency a literature review DONG
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Hong-tan HAN Gang ZHU Xiao-chen et al. Department 2 of Encephalopathy Dongfang Hospital Affiliated
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to Beijing University of Chinese Medcine Beijing 100078 China
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Corresponding author GUO Rong-juan E-mail dfguorongjuan@ 163. com
【Abstract】 Liver stagnation and spleen deficiency syndrome is one of mon syndromes of de-
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pression which is generally transformed from the syndrome of stagnation of liver qi. So far the basic re-
search on depression due to liver stagnation and spleen deficiency generally acknowledged that when liver
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stagnation and spleen es up the following phenomena appear the imbalance in the body's
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nerve-endocrine-immune system the abnormality of the brain gut axis as well as the dysfunction of EEG.
The effector mechanism of clinica