Survivin和VEGF在尖锐湿疣中的表达及其相互关系 (作者:___________单位: ___________邮编: ___________) 【摘要】目的:探讨凋亡抑制基因生存素(Survivin)和血管内皮细胞生长因子(VEGF)在尖锐湿疣(CA)组织中的表达情况及其相互关系。方法:免疫组化法检测51例CA组织、15例正常皮肤组织中Survivin及VEGF蛋白的表达情况。结果:Survivin和VEGF在CA及正常皮肤组织中的阳性率分别为60%(34/51)、%(40/51)%(1/15)、%(4/15)。CA组织中Survivin和VEGF表达的阳性率与正常对照组比较差异均有显著性,且CA中两者的阳性率呈明显的正相关(P )。结论:Survivin和VEGF与CA的发生、发展密切相关,且两者在CA中的表达具有一定的协同性。 【关键词】生存素;血管内皮生长因子;尖锐湿疣 Abstract: Objective: To measure the expression and to determine the correlation of Survivin and vascular endothelial growth factor (VEGF) in the lesions of Condyloma Acuminatum (CA). Methods:Survivin and VEGF were measured with immunohistochemical technique in 51 cases of CA and 15 specimens of normal skin. Results: The expressions of Survivin and VEGF in CA were 60% (34/51) and % (40/51),respectivly,in normal skin were % (1/15) and % (4/15)(both P ). There was strong positive relation ship between Survivin and VEGF in CA (x2=,P ). Conclusion: Survivin and VEGF may play important roles in the development of CA,and their effect in CA is synergetic. Key words: Survivin;vascular endothelial growth factor;condyloma acuminatum 尖锐湿疣(condyloma acuminata,CA)临床上增生快,治疗后常易复发,且部分病例有转化为恶性肿瘤的可能,因而日益受到人们重视。CA的发生机制至今尚未完全明了,细胞凋亡和增殖异常可能是其重要机制之一。生存素(Survivin)是近年研究发现的最强的凋亡抑制因子,并与细胞增殖和血管生呈正相关。血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)是目前已知的最强有力的血管生成因子
