丘脑底核深部电刺激治疗帕金森病.doc

丘脑底核深部电刺激治疗帕金森病
作者:程振国,高国栋,王学廉,李维新

【关键词】帕金森病
【Abstract】 AIM: To explore the principle, the operative method and the effects for the treatment of Parkinson’s disease (PD) by deep brain stimulation of subthalamic nucleus (STNDBS). METHODS: Thirty patients with PD were selected for STNDBS. Surgery was performed under local anaesthesia using CosmanRobertsWells (CRW) model frame. Implants were placed into STN CTbased stereotaxy by microelectrode guidance and intraoperative test stimulation. All patients were followed and evaluated for 6-12 months after surgery. RESULTS: According to UPDRS and Webster scores, the scores of all our patients decreased significantly after the electrical stimulation of the STN (P<) and the symptoms of PD were alleviated significantly. The mean dose of dopaminergic drugs was reduced (P<) and no severe permanent plications were found. CONCLUSION: Electrical stimulation of the STN is safe and effective treatment for PD. The severity of many symptoms can be alleviated by adjusting the parameters, and so the dose of levodapa can be reduced.
【Keywords】 Parkinson’s disease; deep brain stimulation; the subthalamic nucleus; stereotaxy
【摘要】目的: 探讨脑深部电刺激(deep brain stimulaiton,DBS)丘脑底核(the subthalamic nucleus, STN)对帕金森病(Parkinson’s disease,PD)的治疗机制、方法和疗效. 方法: PD患者30例,应用CT和微电极导向立体定向技术将刺激电极植入丘脑底核,术前1 wk及术后1 mo采用UPDRS和Webster评分,随访6~12 mo. 结果