双鼻塞持续气道正压通气与氨溴索联合治疗新生儿呼吸窘迫综合征.doc

双鼻塞持续气道正压通气与氨溴索联合治疗新生儿呼吸窘迫综合征        【摘要】     目的:探讨在基层医院进行双鼻塞持续气道正压通气(CPAP)与盐酸氨溴索联合应用治疗新生儿呼吸窘迫综合征(NRDS)的疗效及临床价值。方法:对23例NRDS患儿进行CPAP通气的同时给盐酸氨溴索静脉注射加雾化治疗,观察治疗前后的血氧饱和度、X线胸片和临床效果。结果:与用药前相比,用药后6hSpO2即明显升高,至12h、24h、36hSpO2仍持续稳定在较高水平,差异有统计学意义。用药6h,呼吸窘迫症状消失4例(%),明显改善18例(%),未减轻3例;48h后,X线胸片显示肺野透明度明显改善18例(%)。23例中治愈20例(87%),1例死亡,2例家属签字放弃治疗。结论:CPAP与盐酸氨溴索联合应用治疗NRDS临床效果满意,经济有效,依从性好,值得在基层医院推广。    【关键词】 盐酸氨溴索;肺表面活性物质;双鼻塞持续气道正压通气;呼吸窘迫综合征       binedwithambroxolintreatingtheneonatalrespiratorydistresssyndrome   JIAYongfeng(ShangluoWomenandChildren’sHospitialofShanxiProvince,ShanxiShangluo 726000,China)  [Abstract]Object:Todiscusstheeffectsandthevalueofthecontinuouspositiveairwaypressure(binedwithambroxolforthedoublestuffynoseintreatmentofneonatalrespiratorydistresssyndrome(NRDS):23casesofNRDSweretreatedwiththeCPAPwhenambroxolwasaddedintravenouslywithatomizationtreatment,andthensaturationsofbloodoxygen,,SpO2wasobviouslyhigher6hoursafterthemedicationandremainedonhighlevel12,24and36hoursafter,(%)andimprovedin  16cases(%),Xsternumdemonstratedimprovementinthelungfieldtransparencyin18cases(%).In23cases,20recovered(87%),1dyed