恩度联合肝动脉化疗栓塞治疗中晚期肝癌28 例[J].pdf

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实用医学杂志年第卷第期
2009 25 19 3295
药物与临床
· ·
恩度联合肝动脉化疗栓塞治疗中晚期肝癌例
28
朱国庆虞希祥郝伟远施昌盛陈斌施振静
摘要目的探讨恩度联合肝动脉化疗栓塞治疗中晚期肝癌的疗效不良反应方法例中晚期原发性肝
: 、。:60
癌患者分为两组实验组例予恩度联合肝动脉化疗栓塞治疗对照组例予常规肝动脉化疗栓塞治疗对
。 28 , ; 32 , 。
治疗前后实体肿瘤疗效血清血管内皮生长因子甲胎蛋白的变化及不良反应等进行分析结果两
、(VEGF)、(AFP) 。:
组不良反应均较轻微实验组治疗后实体肿瘤缓解率和转阴率较对照组显著提高两组患者血清
, AFP (P < );
表达水平在术后均显著升高实验组术后血清表达水平能迅速下降与对照组比较差异有统
VEGF 3 d , 7 d VEGF ,
计学意义结论恩度联合肝动脉化疗栓塞治疗中晚期原发性肝癌的肿瘤的近期疗效显著副
(t = ,P < )。: ,
作用小安全性好是一种值得临床应用的治疗方法
, , 。
关键词肝肿瘤化学栓塞治疗性血管内皮生长因子甲胎蛋白
; , ; ;
Endostar plus transcatheter arterial chemoembolization for advanced hepatocellular carcinoma ZHU Guo-qing,
YU Xi-xiang, HAO Wei-yuan, SHI Chang-sheng, CHEN Bin, SHI Zhen-jing. Interventional Department of the Third
Affiliated Hospital of Wenzhou Medical College, Ruian 325200, China
Corresponding author:YU Xi-xiang E-mail:zgq3870@
【Abstract】 Objective To investigate the therapeutic effects and adverse effects of endostar plus transcatheter
arterial chemoembolization (TACE) on advanced hepatocellular carcinoma (HCC). Methods 60 patients with HCC
were assigned to receive endostar plus TACE (experiment group, n = 28) or TACE alone (control group, n = 32). The
therapeutic effects and adverse effects, serum levels of vascular endothelial growth factor (VEGF) and alpha-fetoprotein
(AFP) were analyzed. Results No obvious adverse effects we