胎儿生长受限与瘦素、胰岛素样生长因子.Ⅰ水平的相关性.doc

【关键词】脐静脉[摘要]目的研究胎儿生长受限(FGR)与瘦素、胰岛素样生长因子.Ⅰ(IGF.Ⅰ)的关系,探讨脐血瘦素、IGF.Ⅰ的临床检测价值。方法采用放射免疫法检测40例正常孕妇(对照组)和24例FGR孕妇(FGR组)的血清与脐血(脐A和脐V)中瘦素和IGF.Ⅰ水平,并对其结果进行相关性分析。结果(1)FGR组血清瘦素及IGF.Ⅰ水平与对照组比较,差异无显著性(P>);(2)FGR组脐血瘦素和IGF.Ⅰ水平均明显低于对照组(P<,P<)。(3)两组孕妇血清瘦素和IGF.Ⅰ水平与脐血瘦素和IGF.Ⅰ水平无相关性(r=,r=-,均P>);脐血瘦素水平与新生儿出生体重呈正相关关系(r=,P<),与胎盘重量亦呈正相关关系(r=,P<);脐血IGF.Ⅰ水平与新生儿出生体重呈正相关关系(r=,P<),与胎盘重量无相关关系(r=,P>)。(4)脐A瘦素和IGF.Ⅰ水平与相应脐V瘦素和IGF.Ⅰ水平差异无显著性(P>)。(5)脐血瘦素与IGF.Ⅰ水平无相关关系(r=,P>)。结论脐血瘦素和IGF.Ⅰ水平与胎儿生长发育状态密切相关;脐血瘦素或IGF.Ⅰ水平降低可能是FGR发生的原因之一;瘦素调控胎儿生长发育没有IGF.Ⅰ的直接参与;脐A与脐V血瘦素及IGF.Ⅰ水平均可作为评价胎儿生长发育的临床指标。[关键词]瘦素;胰岛素样生长因子.Ⅰ;胎儿生长受限;脐动脉;脐静脉Therelationshipbetweenfetalgrowthreatrictionandlevelsofleptin,IGF.ⅠJIANGXiao-qing,WANGJing,YUHong(DepartmentofObstetricsandGynecology,ZhongdaHospital,SoutheastUniversity,Nanjing210009,China)Abstract:ObjectiveTostudytherelationshipbetweenfetalgrowthreatriction(FGR)andlevelsofleptin,insulin-likegrowthfactorI(IGF.Ⅰ).MethodsThelevelsofleptinandIGF.Ⅰinserumandcordbloodin24FGRpregnantwomen(FGRgroup)and40normalpregnantwomen(controlgroup)weremeasuredbyradioimmuno-assay(RIA).ⅠinserumbetweenFGRgroupandcontrolgrouprevealednostatisticalsignificance(P>)..ⅠincordbloodinFGRgroupwerenotablylowerthanthoseofcontrols(P<;P<)..Ⅰwerenotcorrelativetothecordbloodlevelsofbothconstituentsintwogroups(r=,r=-,P>);whereasthelevesofleptinincordbloodwerepositivelycorrelatedwithfetusbirthweightandplacentaweight(r=,P<;r=,P<).ApositivecorrelationexistedbetweenthelevelsofIGF.Ⅰincordbloodandthebirthweightoffetus(r=,P<),butanegativecor-relationinplacentaweight(r=,P>)..Ⅰ.Ⅰ