101例使用5年以上短效口服避孕药的安全性调查101例使用5年以上短效口服避孕药的安全性调查中国计划生育学杂志2007年第6期总第140期101例使用5年以上短效口服避孕药的安全性调查潘亚娥李秀春王育青摘要目的::对连续服用国产短效口服避孕药5年以上101例(服药组)采用问卷调查和体格检查,并与5年前使用输卵管结扎103例妇女(结扎组),平均体重均无统计学差异,但结扎组平均年龄高于服药组(P<),妊娠次数与孩子数明显高于服药组(P<).结果:服药组组内前后月经情况比较,服药后月经周期缩短,经量减少(P<),经期?8天者比率显着减少,无痛经主诉的比率明显增加(P<);服药组和结扎组组间比较,经期?8天者的比率明显低于结扎组,经量显着低于结扎组(P<),轻度痛经者的比率明显高于结扎组(P<);两组生殖系统疾病比较,乳腺小叶增生的发生率服药组明显低于结扎组(P<);:长期使用短效口服避孕药总体是安全的,—,:Toevaluatethehealtheffectsoflong—termuseof8hort—:Questionnaireinvestigationandphysicalexaminationwereadoptedtoevaluatethesafetyof101caseswhouseddomesticshort—termeffectiveoralcontraceptivescontinuouslyformorethanfiveyears(testgroup),paredwith103caseswhowereperformedtuballigationfiveyearsago(controlgroup).Therewerenosignificantdifferencesintheaveragetimeofcontracep—tivemeasuresandbodyweightbetweentwogroups,buttheaverageageoftheligationgroupWasolderthanthatofthetestgroup(P<).Thegravidityandparityoftheligationgroupweresignificantlyhigherthanthetestgroup(P<).Results:Inthetestgroup,themenstrualcycleandtheamountofmenstrualbleedingreducedaftertreatment(P<).Therateofthemenstrualperiodformorethaneightdaysandmenstrualpainweresignificantlyreduced(P<).Therateofthemenstrualperiodforovereightdaysandmenstrualbleedingamountinthetestgroupweresignificantlylowerthanthatofintheligationgroup(P<).Therateofslightmenstrualpainofthetestgroupwassignificantlyhigherthanthatoftheliga—tiongroup(P<0,05),Theincidenceofreproductive,systemdiseasesandhyperplasiaofbreastlobulesinthetestgroupwassignificantlylowerthanthatofintheligationgroup(P<).Therewerenosignificantdifferencesintheincidenceofhy—pertensionandotherdisea
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