芍药属药用植物亲缘学的研究.pdf

1;?≤目录缩略语及术语简表······························································中文摘要·················································一”·······一··”··”ABSTRACT·············一·········”··”·”·····”··········”·············“3前5第一章芍药属相关文献综述················································9第一节芍药属系统分类、地理分布与分布格局的形成·····························9第二节芍约属化学成分与药理活性研究·········································15第三节芍药属植物的化学成分分析研究概况·····································59第二章牡丹种子化学成分和生物活性研究·································72第一节研究结果·····························································73第二节新化合物的结构解析···················································77第三节实验部分·····························································92第四节已知化合物结构鉴定···················································94第五节牡丹种子主要化合物的生物活性研究·····································105第三章芍药属植物种子主要化学成分分析研究······················································130第三节牡丹和芍药种子中主要化学成分的动态变化研究···························144第四章白芍、赤芍和牡丹皮化学成分快速分析比较研究····················15l第五章芍药属主要药用植物根部的次生代谢产物研究·····················165第六章芍药属植物亲缘学讨论·············································183第一节芍药属植物的化学亲缘学讨论···········································183第二节芍药属药用植物亲缘学讨论············································19l197致谢””·”···”一··”·“·””···一··..·····””··”·····”””“···”·····19920l203附图··一······””·····”·······”·····”·······”·········”·············204缩略语及术语简表缩略语及术语简表中文摘要芍药属药用植物亲缘学研究博士生:何春年导师:肖培根院士彭勇研究员(清华呋学(医学部)&北京仂和医学院中国医学剥学:院药用植物硼究所,=l芍药科(Paeoniace∞)系单属科,由芍药属(尸白PD玎衙)从毛莨科独立而来。芍药属约35种,划分为3个组,即牡丹组、北美芍药组和芍药组,中国是芍药科植物的起源、演化、分化发展及多样性中心,特别是其中的牡丹组为我国特有植物。为了更深入地探讨芍药属植物的药用亲缘关系,阐明该属植物的分类学地位和种间关系,为资源利用和保护提供依据,我们首先在对牡丹种子进行系统的化学成分研究基础上,系统分析中国产芍药属主要药用植物种子的化学成分含量与分布特点,通过数据统计分析揭示其化学分类学意义;通过快速色谱分析白芍、赤芍和牡丹皮的指纹特征,采用化学计量学方法分析三味药材化学成分的差异,探讨三味药材药性的差异与化学成分差异之间的相关性;并详细对芍药属牡丹组和中国产芍药组植物的色谱指纹图谱进行研究和分析,运用统计分析方法进行化学分类学探讨,揭示芍药属植物根部主要次生代谢产物分布特点。在上述研究的基础上,探讨芍药属(科)的药用植物亲缘学关系,同时根据药用植物亲缘学理论对牡丹种子资源利用的前景进行展望。本文对牡丹(Ps幼哥甜砌D册)种子进