隆起糜烂性胃炎脾胃湿热证和tk1及细胞超微结构相关性的研究.pdf

一目录 III fl80391 9 中文摘要???????????????????????????1 英文摘要??????????????????????????2 刖吾????????????????????????????4 正文临床资料与方法?????????????????????6 细胞超微结构图0 000 00 00 90 00 00 00 00 010 分析与讨论????????????????????????14 问题与展望?????????????????:?????..16 结论??????????????????????????17 参考文献??????????????????????????18 致谢··?·?·??·??···?·?·??·?·?·??..?.?.?.?.?...?..20 附录??????????????????????????21 文献综述??????????????????????????22 作者简介??????????????????????????26 i分隆起糜烂性胃炎脾胃湿热证与TKl及细胞超微结构相关性研究王永飞中文摘要目的:通过观察隆起糜烂性胃炎(Raised Erosive Gastritis,REG)脾胃湿热证与胸腺嘧啶核苷激酶1(Thymidine kinase 1,TKl)的关系,并通过透射电镜观察细胞的超微结构,探讨中医证型与细胞增殖、凋亡之间的相关性,以期更好的协助中西医结合临床防治隆起糜烂性胃炎。方法:选择内镜下诊断为REG的门诊患者61例,根据中医辩证分为脾胃湿热证组、脾胃虚弱证组,其中脾胃湿热证组30例,脾胃虚弱证组3l例,并设正常对照组(Hp 均阴性)11例。所有受试者均空腹行胃镜检查,取胃窦部活检标本进行TKl的测定,并选择REG8例行透射电镜进行细胞超微结构观察。结果: 1REG患者与正常对照组比较TKl有增高趋势,差异有统计学意义(p<)。 2REG脾胃湿热证组、脾胃虚弱证组TKl的表达与正常对照组经统计学分析,差异均有统计学(p<);脾胃湿热证组、脾胃虚弱证组间TKl表达情况,经统计学分析,无显著性差异(p>)。 3REG超微结构可见增生现象。 4REG脾胃湿热证组细胞超微结构观察增生较脾胃虚弱证组明显。结论: lREG胃黏膜处于增殖活跃状态。 2REG脾胃湿热证细胞增殖活跃。关键词:隆起糜烂性胃炎脾胃湿热证TKl细胞超微结构 Study theRelationship between theTKl,C ellUltrastructure and theRaised Erosive Gastritis withSpleen·-Stomach Dampness-Heat Syndrome Wang Yongfei ABSTRACT objective:To study therelationship between theexpression ofThymidine l(inase Ultrastructureof thecellswasobservedby transmissionelectronmicroscopy andRaised ErosiveGastritiswithspleen-stomach dampness study therelationship bet、7Ireen TCM syndrome and cellproliferation and order toassistant the treatment ofRaised Erosive Gastritis winlintegrated traditionalChineseandWestern Medicine. Method:6 Raised Erosive Gastritispatients whoses syndromes meet withspleen stomach-dampness-heat(SSDH),spleen stomachqi·defieiency(SSQD)according toTCM 斌cs wereselected were30 patients inspleen-stomach dampness-heat(SSDH)group,3 patients inspleen stomachqi—deficiency(SSQD)group,. Allsubjects accepted gastroscopy thesamples from thegastric antrum,d