还原型谷胱甘肽联合苦参碱治疗慢性乙肝的临床观察.doc

还原型谷胱甘肽联合苦参碱治疗慢性乙肝的临床观察.doc还原型谷胱甘肽联合苦参碱治疗慢性乙肝的临床观察作者:覃后继,覃雪英,何延专【摘要】冃的观察还原型谷胱甘肽联合苦参碱对慢性乙型肝炎的疗效。方法将163例慢性乙型肝炎患者随机分为两组,治疗组83例给予苦参碱及还原型谷胱甘肽治疗;对照组80例单纯给予还原型谷胱甘肽。两组疗程均为8周。观察患者血清内氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)>碱性磷酸酶(ALP)>r谷氨酰转肽氨酶(rGT)、总胆红素(TB订)、透明质酸(HA)、层黏蛋白(LN)、IV型胶原(IVC)、III型胶原(PCIII)及门静脉内径(D)值变化情况。结果治疗组治疗后的ALT、AST、ALP、rGT、TB订、HA、LN、TVC、PCIU均降低,D值变小,与治疗前比较有显著性差异(P<)o与对照组治疗后比较,改善更明显,有非常显著性差异()。%%,差异有非常显著性(P<)。结论还原型谷胱甘肽联用苦参碱治疗慢性乙型川炎,在降酶、退黄、抗肝纤维化、缩小D值及改善临床症状方面有协同作用。【关键词】还原型谷胱甘肽;苦参碱;慢性乙型肝炎【 Abstract ・83patientsintreatmentgroupweregivenreducedglutathioneandmatrine・80casesincontrolgroupweresimplygivenreducedglutathione・Twogroupsweretreatedforeightweeks・Thechangesofserumalanineaminotransferase(ALT),aspartateaminotransferase(AST),alkalinephosphatase(ALP),rglutamyltranspeptidaseinammonia(rGT),totalbilirubin(TBil),hyaluronicacid(HA),laminin(LN),typeIVcollagen(IVC),collagentypeIII(PCITT)andtheportalveindiameter(D),AST,ALP,rGT,TBil,HA,LN,IVC,PCIIIintreatmentgroupweresignificantlydecreasedafter8weekstreatment,andtheDvaluewasreducedtoo(P<).Comparewiththecontrolgroupaftertreatment,thereweresignificantdifferences(P<).%and67・5%,that'sasignificantdifference(P<)・binedreduc