重性抑郁症患者脑灰质体积磁共振成像的研究.pdf

硕士学位论文中文摘要摘要目的:利用磁共振成像(ic resonance imaging,MRI) 技术检测重性抑郁症患者与健康对照在脑灰质体积的差异,探讨抑郁症可能的生物学标记,从而推测抑郁症可能的病理机制,为临床诊断提供新线索。研究方法:以46例重性抑郁症患者()和46例健康对照为研究对象。要求重性抑郁症患者组的 HAMD评分>17分。所有受试者在入组后接受核磁共振检查,进行头部 MRI扫描。以基于体素的形态测量法(optimized voxel—based morphometry,VBM)的对两组被试的结构MRI图像的灰质体积进行预处理,得到脑结构的调整和未调整的图像,分别代表脑灰质体积,脑白质体积,脑灰质密度和脑白质密度。采用T检验的统计分析,并引入年龄和灰质值作为协变量,比较患者组和对照组脑灰质体积的差异。结果:46例重性抑郁症患者及46例健康对照均完成了临床资料的采集及MRI扫描。结果发现:; 受教育年限在研究组为(±)年,对照组为(±) 年,两组无显著性差异;而研究组的HAMD评分为(±), 对照组为(±),两组间有非常显著差异。:将年龄和灰质值等作为协变量后,重性抑郁症患者组与健康对照组的脑灰质比较的统计分析后发现,患者组在左侧额上回,左侧额中回脑灰质体积减小,而右侧杏仁核的脑灰质体积增大。硕+学位论文中文摘要结论:重性抑郁症患者的脑灰质体积改变主要涉及额叶和杏仁核等脑区。抑郁症患者存在多个脑区的结构异常,以及多个脑区之间的相互联结出现异常,导致“大脑半球失联结综合症”,尤其是额叶皮质一杏仁核联结的功能失调,可能是抑郁症病理机制的关键所在。关键词: 重性抑郁症,影像学,脑结构,灰质,认知功能硕十学位论文英文摘要 AMIU Study ontheVolume Changes ofGray Matter inPatients withMaj orDepressive Disorder ABSTRACT obj ective:Using ic resonance imaging(MRI),we examined thevolume differenceofgraymatter(GM)between major depressiove patients andhealthy controls,toinvestigate thedisease—specific biological makers,and toprovide new clues andevidences for theunderstanding of themechanism anddiagnosis ofdepression disorder. Methods:46 cases ofmajor depressive disorderpatients(consistent with DSM·IV maj or depression diagnostic criteria)and 46 healthy controls were studied,divided intotwo groups:patient group and control groupR HAMD scores ofthepatient group must behigher subj ectsmust finish their head -based morphometry method(voxel-based morphometry,VBM)were tested against thetwo setsoftheimage ofgray mattervolume ofthebrain structure byMⅪ. The adjusted images represented thebrain铲ay mattervolume,white mattervolume,cerebral gray matterdensity and gray matterdifferencebetween thepatients andcontrols was examined by analysis of age,voxel-level,or both ofthem,were introduced ascovariants inthestatisticmodels toexamine theireffects on VBM results。 Resu