胃肠道间质瘤非同期肝转移的治疗.doc

胃肠道间质瘤非同期肝转移的治疗.doc胃肠道间质瘤非同期肝转移的治疗摘要:目的总结胃肠道间质瘤非同期肝转移的诊断及治疗经验。方法回顾性分析13例胃肠道间质瘤非同期肝转移的临床资料。结果本组13例,均为胃肠道间质瘤术后发现有肝转移,同时并复发或其他部位转移。其中8例来源于胃,2例位于十二指肠,1例位于空肠,2例位于结肠。临床表现均有肝功能不同程度受损:Child-pugh分级A级3例,B级6例,C级4例。2例并局部复发,1例并腹腔转移,1例并腹膜后转移。本组均行甲磺酸伊马替尼治疗,4例术前行介入治疗(TACE),3例行射频治疗,9例行手术治疗。本组13例均获随访,%,%。结论靶向治疗加手术切除、TACE、射频的综合治疗是治疗本类患者最有效的治疗方法。关键词:胃肠道间质瘤;肝转移;甲磺酸伊马替尼;手术Abstract:ObjectiveToevaluatediagnosisandtreatmentoflivermetastasisgastrointestinalstromaltumor(GIST),bothinpostopretivegastrointestinalstromaltumorlivermetastases,8caseshadtheprimarytumorinstomach,2caseinduodenum,1caseinjejunum,:Child-pugh,classAin3cases,classBin6cases,-urredinallcases,includingtumorrecurrenceandmetastasizedtolivertissuesin2cases,metastasizedto1ivertissuesin4cases,metastasizedtoliverandabdominalcavityin1case,-upviews13caseshadtakenimatinibmesylate,eptedinterventionaltherapy(TACE),9casesreceptedsurgicaltreatment,-%and3-%.ConclusionTargetedtherapyandsurgery,TACE,radiofrequencyintegratedtreatmentisthemosteffectivetreatmentfori