Management of acne Canadian clinical practice guideline：痤疮的加拿大管理临床实践指南.pdf

Guidelines CMAJ ?2015 8872147 Canada Inc. or its licensors CMAJ 1 CME e is one of the most burdensome dis - eases globally. 1,2 Its prevalence among those aged 12 to 24 years is estimated to be 85%, although it can persist beyond young adulthood despite treatment. 3–5 Acne can adversely affect quality of life 6–13 and may lead to emotional distress and physical scarring. 14,15 The clinical presentation of acne (Figure 1) varies from edonal to edonal and inflammatory acne. 16 Since the last Canadian acne guideline was published in 2000, 17 evidence for multiple addi - tional treatments has been published. Thus, there was an unmet need for an updated, systematic- ally developed, evidence -based Canadian acne clinical practice guideline. This guideline pro - vides mendations adapted to the Canadian health care system to assist Canadian health care providers in the diagnosis of acne vulgaris, including investigations where appropriate; it also provides updated information on the patho - genesis of acne, outlines methods for evaluating acne severity, provides evidence -based guidance on treatments for acne vulgaris and mends treatments for acne according to severity. To support clinical practice, menda - tions are made for three categories of acne sever - ity: comedonal acne, which consists of small white papules (edones) or grey–white papules (edones), which