玛咖提取物的激素样活性实验研究.doc

玛咖提取物的激素样活性实验研究.doc玛咖提取物的激素样活性实验研究
【摘要】
目的初步研究玛咖提取物的激素样活性作用。方法采用雄性
去势小鼠，经灌胃玛咖不同提取物22 d后，观察各组小鼠前列腺和精囊腺的重 量并测定血清中睾丸酮的含量。用幼龄雌性小鼠，灌胃玛咖醇提物10 d后，观 察各组小鼠子宫、卵巢重量以及阴道上皮角化细胞。结果玛咖提取物可以显著提 高雄性去势小鼠前列腺和精囊腺重量，但并不升高血清睾丸酮水平。玛咖醇提取 物对雌性幼年小鼠子宫、卵巢重量以及阴道上皮角化细胞没有显著影响。结论玛 咖具有弱的雄激素样作用，但对幼年雌性小鼠未显示雌激素样活性。
【关键词】
玛咖雄激素样作用 雌激素样作用
Abstract : ObjectiveTo study the testosterone-like and estrogen-like
effects of extract of Maca(Lepidium meyenii Walp.) in vivo. MethodsAqueous , ethanol and ethereal extracts of Maca were orally administered castrated mice for 22 days
・ The testosterone-like effects were measured by prostate seminal vesicle wEight, and serum testosterone level. Infancy female mice were administe「ed to ethanol extract of Maca for 10 days. The estrogen-like effects were measured by uterus and ovary wElght, and the ratios of keratinocyte in vaginal smear. ResultsMaca extract significantly increased prostate seminal vesicle weight of castrated mice, while had no effect on the serum testosterone level. There was no remarkable effect on uterus and ovary weight, as well as on the ratios of keratinocyte of vaginal epithelial cell. ConclusionMaca has weak testosterone-like effect, but no estrogen-like effect on infancy female mice.
Key words : Maca(Lepidium meyeni Walp) ; Estrogen-like effect ; Testosterone-like effect
玛咖（Maca ）为十字花科独行菜属植物Lepidium meyenii 似萝卜的地下根茎［1 ］，原产于海拔3500-4500m的南美安第斯山区，在南美 已有五千八