肾功能检验.ppt

Laboratory tests of renal function
Junfu Huang
Southwestern Hospital
TMMU
Anatomy of Kidney
Functions of the kidney
Excretion of Metabolite Waste: urea, uric acid, creatinine
Urine Production, regulation of homeostasis, water, acid base balance
Endocrine Function: renin, erythropoietin, 1,25 -dihydroxycholecalciferol
Renal function tests
Detect renal damage
Monitor functional damage
Distinguish between impairment and failure
Kidney Function
A plumbers view
How do you know it’s broken?
NO Urine!
Clinical symptoms
Tests
Where can it break?
Pre-renal
Renal
Post-renal
Laboratory tests of renal function
Glomerular Function Tests
Renal Tubular Function Tests
Section 1 Investigation of Glomerular Function
Renal Blood Flow: 1200-1400ml/min
Renal Plasma : 600-800ml/min
20% of plasma: glomerular filtration
GFR:Glomerular Filtrtion Rate
Concept
Renal Clerance
Concept
Virtual volume of plasma from which the substance in question has pletely removed during a given time interval.
C=UV/P
U:urine concentrtion P:plasma con.
V:urine flow rate