PTR-MS & Quadrupole
ion guide
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Outline
PTR-MS
Quadrupole ion guide
Next work
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PTR-MS
Introduction
Overview
Development
Application
Component
Ion Source
Drift Tube
Quadrupole mass analyzer
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PTR-MS
[J].分析化学,2008,36(1)
细胞
检测器
ATP
质谱图
Overview
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PTR-MS
Development
1966: and developed chemical ionization;
1969:Flowing afterglow and flow drift tube technique (FDT) developed by Ferguson and colleagues ;
1990s:On the basis of SIFT-MS,Innsbruke’s Lindinger team put forward the PTR-MS technology for the first time in combination with chemical ionization theory (1996) and drift tube model (1969).
In June of 1995, Lindinger: Acetonitrile and benzene in the breath of smokers and non-smokers investigated by PTR-MS;
In July of 1995, Lindinger: PTR-MS: Online Trace Gas Analysis at ppb Level.
1998,the first commercial PTR-MS instrument was produced by IONICON Analytik.
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Schematic of PTR-TOF-MS
Blake R S, Whyte C, Hughes C O, et al. Demonstration of proton-transfer reaction time-of-flight mass spectrometry for real-time analysis of trace volatile organic compounds.[J]. Analytical Chemistry, 2004, 76(13):3841-5.
Hansel A,et al. Proton-transfer-reaction mass spectrometry (PTR-MS): on-line monitoring of volatile organic compounds at volume mixing ratios of a few pptv[J]. Plasma Sources Science & Technology, 1999, volume 8(2):332-336(5).
Schematic of PTR-MS
PTR-MS
Development
High sensitivity(a few pptv)
Multichannel data acquisition
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Applications
Air quality testing
(Real-time online quantitative measurements of trace VOCs)
Biological research
(Monitor the response of plant leaf wounds)
Food science and aroma industry
(Research on aroma, Production process control)
Disease diagnosis
(Lung cancer,Rectal cancer,diabetes)
PTR-MS
…
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Ion Source (H3O+ Generator)
[J].质谱学报,2015,36(1)
Structure of Double Hollow Cathode Discharge
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