孟鲁司特-1.pdf

Neuropharmacology 79 (2014) 707e714
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Neuropharmacology
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Montelukast targeting the cysteinyl leukotriene receptor
1 ameliorates Ab1-42-induced memory impairment and
neuroinflammatory and apoptotic responses in mice
Jin’e Lai a,1, Meng Hu a,1, Hao Wang a, Mei Hu a, Yan Long a, Ming-xing Miao a, Jia-chang Li a,
Xiao-bing Wang b, Ling-yi Kong b, Hao Hong a,*
a Department of Pharmacology, China Pharmaceutical University, Tong Jiaxiang, Nanjing 210009, China
b State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
article info abstract
Article history: Montelukast, known as a cysteinyl leukotriene receptor 1 (CysLT1R) antagonist, is currently used for
Received 31 July 2013 treatment of inflammatory diseases such as asthma. Here, we investigated effects of montelukast on
Received in revised form neuroinflammatory, apoptotic responses, and memory performance following intracerebral infusions of
6 January 2014