THE CHARACTERIZATION OF ANTIZYME IN DEVELOPING Xenopus Laevis ....ppt
THE CHARACTERIZATION OF ANTIZYME IN DEVELOPING Xenopus laevis EMBRYOS Alexandra Silveira and Charles Toth Department of Biology Providence College, Providence, RI Protein Degradation Cell cycle and proliferation Differentiation and development Stress response Genesis of works Modulation of cell surface receptors Regulation of immune response Apoptosis Transcriptional regulation Pathogenesis Cancer, cystic fibrosis, neurodegenerative diseases Charles Toth, Providence College Protein degradation by the 26S proteasome t/bcbp/molbiochem/MBWeb/mb2/part1/ Protein degradation by the 26S proteasome ODC degradation – a unique protein degradation pathway John Mitchell, University of Northern Iowa John Mitchell, University of Northern Iowa ODC and Polyamine Biosynthesis /mitchellab/ Polyamines pounds found bound to RNA and DNA in cells High levels are toxic Necessary for cell growth and survival gate currents of ion channels have effects on chromatin condensation and transcriptional regulation neutralize negative charges of RNA and DNA regulate the levels of AZ provide a necessary postranslational modification to eIF-5a protein /zoofysiol/Cellprolif/Research/ AZ Functions ODC degradation Anti-proliferative effect on cells Blocks uptake of additional polyamines when polyamine levels are too high High levels of polyamines in turn regulate AZ through a ribosomal frameshift /mitchellab/ Ribosomal Frame-Shifting High levels of polyamines cause a ribosomal frame shift that produces an active form of AZ. Without the ribosomal shift a truncated and inactive AZ is formed. Why study antizyme? Studying the unique ODC degradation pathway can lead to a better understanding of ubiquitin mediated protein degradation the many roles of polyamines in the cell AZ is a member of an ancient gene family AZ1 and AZ2 widely expressed and involved in ODC degradation AZ3 is testis specific
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