profile论文论文.pdf

monitor profile DDT Vol. 7, No. 17 September 2002
of schizophrenia. Combining dopamin- lack functional receptor. Individuals who Profile
ergic and serotonergic activity could are homozygous for this defect are highly
be the way to develop atypical antipsy- resistant to HIV-1 infection, whereas het- Calcium phosphate ceramics as
chotics, those that are known to bind erozygous individuals show significantly carriers for bone therapeutic agents
to the dopamine D2 and serotonin 5-HT delayed progression to AIDS. As a result Conventional means of administering
receptors. of these discoveries, many efforts to therapeutic agents generally include oral
Recent work has focussed on the search develop CCR5 antagonists have been medication, eye drops, ointments, intra-
for compounds that share affinity for undertaken. venous injections and patches. However,
dopamine D2 as well as serotonin 5-HT1A A library strategy was developed with the concept of targeted drug delivery to
receptors [1]. A small library of 21 com- the aim of discovering novel pharma- the site-of-action remains of major inter-
pounds was synthesized in solution. The cophore elements, or novel combinations est to improve ther