该论文来源于网络，本站转载的论文均是优质论文，供学习和研究使用，文中立场与本网站无关，版权和著作权归原作者所有，如有不愿意被转载的情况，请通知我们删除已转载的信息，如果需要分享，请保留本段说明。 [摘要]目的：評价外用30%水杨酸联合米诺环素对丘疹脓疱型玫瑰痤疮的疗效。方法：选择35例诊断为丘疹脓疱型玫瑰痤疮的患者，随机选取半侧面部作为试验侧，在口服米诺环素（100mg，1次/d）基础上，试验侧外用30%超分子水杨酸治疗，每2周治疗1次，共3次，并联合使用保湿剂（2次/d）;另一侧作为对照侧，在口服米诺环素的基础上使用保湿剂，2次/d。在治疗前及最后一次治疗后2周进行随访，通过炎症性皮损计数、临床医师红斑评估量表及MX18测定的皮肤红斑指数E值来判断皮肤炎症程度。通过测定皮肤角质层含水量、经皮失水量等皮肤屏障相关指标观察水杨酸对表皮通透性的影响。结果：共纳入患者35例，其中30例完成了试验，试验侧整体疗效优于对照侧，与对照侧比较能更早地改善丘疹脓疱及红斑，4周治疗结束后，试验侧红斑程度评分、红斑E值及TEWL改善优于对照侧，差异有统计学意义（P<）;治疗4周后，试验侧与对照侧角质层含水量较治疗前差异无统计学意义（P>）。结论：30%超分子水杨酸联合米诺环素治疗玫瑰痤疮，能够最大程度地减轻患者慢性炎症反应，有助于丘疹脓疱及红斑改善，同时在治疗早期阶段可促进皮肤屏障功能的修复。 [关键词]水杨酸;玫瑰痤疮;皮肤屏障;炎症;疗效 [中图分类号]+4 [文献标志码]A [文章编号]1008-6455（2020）09-0014-04 Clinical Efficacy of Supramolecular Salicylic Acid Combined with Minocycline in the Treatment of Rosacea ZHOU Xing1， YAO Xin-yu2， LI Yu-zhen3 [ of Dermatology， Beijing Hospital，Beijing 100007，China; of Dermatology （and Vennerology），Peking University First Hospital， Beijing Key Laboratory of Molecular Diagnosis on Dermatoses， National Clinical Research Center for Skin and Immune Disease，Beijing 100034，China; of Dermatology，the 2nd Affiliated of Harbin Medical University， Harbin 150001，Heilongjiang，China] Abstract： Objective The trail was designed as a split-face study to investigate the efficacy and safety of combined application of 30% salicylic acid and minocycline in papulopustular rosacea patients. Methods Thirty-five patients diagnosed as papulopustular rosacea were enrolled to this study. All the patients were instructed to take oral minocycline 100mg per day， combined with the medical moisturizing cream， twice per day. 30% salicylic acid was applied to the randomly allocated half-side of face （E-side） for three times at 2 weeks interval. The other side was noted as C-side. According to the number of inflammatory lesions， the subjective a
