非那雄胺减少前列腺电切术中出血的研究.pdf

·11318· 中华临床医师杂志(电子版)2013 年 12 月第 7 卷第 24 期 Chin J Clinicians(Electronic Edition),December 15,2013,,
·临床论著·
非那雄胺减少前列腺电切术中出血的研究
杨宁强尚攀峰葛华
【摘要】目的探讨术前服用非那雄胺减少经尿道前列腺电切术(TURP)中出血的疗效及机制。
方法随机对 96 例住院行 TURP 的患者进行分组,其中 A 组 23 例服用非那雄胺 3 个月;B 组 32 例服用非
那雄胺 1 个月;C 组 20 例服用非那雄胺及坦索罗辛 3 个月;D 组 21 例未服用任何前列腺增生症方面的药。
术中计算失血量,术后检测前列腺组织中微血管密度(MVD),并比较各组之间的差异。结果 A 组与 B
组术中出血量差异无统计学意义(P>),但前列腺 MVD 差异有统计学意义(P<);A 组与
C 组术中出血量及 MVD 均无统计学差异( P>);与 D 组比较,A、B、C 组术中出血量和前列腺 MVD
明显下降,差异有统计学意义(P<)。结论良性前列腺增生患者术前服用非那雄胺 1 个月以上再行
电切术,可明显减少术中出血。
【关键词】前列腺增生; 非那雄胺; 坦索罗辛; 失血,手术

The research of Finasteride and Tamsulosin to reduce hemorrhage during TURP YANG Ning-qiang*,
SHANG Pan-feng, GE Hua. *Department of Urology, The Second Hospital of Lanzhou University, Lanzhou
730030, China
Corresponding author: SHANG Pan-feng, Email: yangnq0488@
【Abstract】 Objective To discuss the clinical effect mechanism of preoperative finasteride and tamsulosin
on decreasing operative bleeding during TURP with patient of benign prostatic hyperplasia. Methods During a
randomized controlled trial, 96 cases of hospitalized patients which were scheduled for TURP were divided into
four groups: 23 of them were received finasteride for over three months(A group), 32 of them were received
finasteride for one month(B group), 20 of them were received finasteride and tamsulosin for thre