医学交流课件：精准医学.ppt

Precision medicine 精准医学
General View
Background
Concepts and branches
Common consensus and different recognitions
molecular mechanism VS precise surgery
genomics ,proteomics and signal-pathway
mini-invasive surgery
appropriate way, appropriate time, appropriate cost
Obama, Jan of 2015
Blueprint: Precision medicine initiative
Development and Background
Medications would be synthesized personally---precisely tailoring therapies to subcategories of disease（Genomics)
Drug development costs have increased
sharply but benefits not satisfied
Considerable health benefits and cost
Potential for drug response or base-line disease risk
Budget Plan＄
Director of the PMI
/
Faces of the Precision Medicine Initiative – NIH Director Dr. Francis Collins
Precision Medicine in Genetic Disease
Genetic Disease
Hallmark
Precision Oncology
Pharmacogenomics
Prevention
Precision Medicine in Genetic Disease
Hallmark of precision medicine--- targeting of a drug to a precise subclass of patients Example:The treatment of cys-ticfibrosis with ivacaftor (gene)
Precision Oncology
Identifying and targeting diseased pathways
Pharmacogenomics Genomic information to individualize drug prescribing
Precise chemotherapy? (our opinions related)
Prevention targeted and cost-effective screening
hypercholesterolemia →myocardialinfarction
1:250 in the population and highly cost-effective in identifying cases for potentially life-saving cholesterol-lowering therapy
Network
Comparison
NIH
1 million individuals’
genomic data
defining novel syndromes
targeted therapeutic
development
ClinGen
Undiagnosed Diseases
Network Institute
Biobanking and Data Sharing
Network Connecting genomic data and medical record data across cohorts from almost 1 million individuals
Comparison
genomic sequence defining novel syndromes and allowing resources to flow toward targeted thera