硫酸氢氯吡格雷片说明书（英文）.pdf

HIGHLIGHTS OF PRESCRIBING INFORMATION - Non-ST-segment elevation ACS (UA/NSTEMI): 300 mg loading dose
These highlights do not include all the information needed to use followed by 75 mg once daily, in combination with aspirin
PLAVIX safely and effectively. See full prescribing information for (75-325 mg once daily)
PLAVIX. - STEMI: 75 mg once daily, in combination with aspirin (75-325 mg
once daily), with or without a loading dose and with or without
PLAVIX (clopidogrel bisulfate) tablets thrombolytics
Initial . Approval: 1997 • Recent MI, recent stroke, or established peripheral arterial disease: 75 mg
once daily ()
WARNING: DIMINISHED EFFECTIVENESS IN POOR

METABOLIZERS
---------------------DOSAGE FORMS AND STRENGTHS----------------------
Tablets: 75 mg, 300 mg (3)
See full prescribing information for complete boxed warning.
• Effectiveness of Plavix depends on activation to an active metabolite -------------------------------CONTRAINDICATIONS------------------------------
by the cytochrome P450 (CYP) system, principally CYP2C19. () • Active pathological bleeding, such as peptic ulcer or intracranial
• Poor metabolizers treated with Plavix at recommended doses exhibit hemorrhage ()
higher c