甲状腺功能减退和亚临床甲减症患者氧化应激指标变化的分析.pdf

显示,其TC、TG、LDL结果明显高于对照组(P<),HDL改变无明显统计学差异。 :(P<O。01;P<),(P<O。05:P<) , 且甲减组患者TG、LDL也明显高于对照组,提示亚临床甲减组及甲减患者均已存在脂质代谢紊乱,易于进一步发生血管内皮的损伤,因此对该两组患者进行规律的血脂监测并进行干预是有必要的。 , MDA和OX—LDL水平显著高于对照组,提示两组患者均处于氧化应激状态并有抗氧化应激能力的下降,这提示我们对亚临床甲减患者即进行抗氧化应激干预是有一定意义的。关键词甲状腺功能减退;亚临床甲状腺功能减退;氧化应激 Objective: Abstract levelofblood lipid andtheoxidative stress lndicatorsinclude malondialdehyde(MDA),Superoxide dismutase(SOD)activity and oxidized lowdensity lipoprotein(ox—LDL)of thehypothyroidism,the subclinical hypothyroidism and the controls were detectedandannalized,which means toknow about theoxidative stress stateofthesubclinical hypothyroidism groups and hypothyroidismgroups,and prove certainbasisoftheintervene tothis state. Materials andMethods: From Aug..2009 toNov 20 indepartment ofendocrinology and thesection for outpatients The people’SHospital ofFeicounty,46 hypothyroidism patients(male in 8 cases,female in28cases,average +)and 44 subclinical hypothyroidism patients(male in20cases,female in24cases,average +)were enrolled in theobservation group,44 healthypersons((male in22cases,female in22cases,average +))with no history ofthyroid diseases were selected members had no hypertension,diabetes,dyslipidemia history、no malfunction ofthe heart,liver,kidney, levelsofblood lipid include TG TC,HDL-C,LDL-C, and theoxidative stress indicators include MDA,SOD activity and OX—LDL were detected,The clinicaldatasuch asheight,weight,blood pressure,and heart ratewere ,BMI Was calculated according difference of above indexes between the3groups were analyzed using testanalysis. Results: parisons ofclinicaldata Only theBMI ofthe two observation groups was significantlyhigher than that inthenormal controls伊<). parisons ofblood lipid data Plasma TC and LDL o