左金丸及反左金丸对热性功能性胃肠疾病模型大鼠胃肠激素分泌的影响.pdf

左金丸及反左金丸对热性功能性胃肠疾病模型大鼠胃肠激素分泌的影响冯淑恰崔海峰周艳华黄颖孙明杰5 【摘要】目的:研究热性功能性胃肠疾病发生的过程中胃肠激素的变化及作用,比较左金丸及反左金丸及方中单味药材的作用差异。方法:选用SD大鼠,以附子、肉桂、干姜、女贞子以1:l:l:l比例,制成2∥ml水煎剂,每天灌胃一次,剂量为10∥蚝。造模6周。造成热性功能性胃肠疾病模型,灌服左金丸及反左金丸、黄连、吴茱萸汤剂进行干预,比较左金丸和反左金丸及方中各单昧药对热性功能性胃肠疾病模型动物血浆中胃肠激素的影响。结果: 模型动物血浆中生长抑素(SS)K)均见明显升高,单味中药黄连可以 K水平,K的水平,而反左金丸及单味 K水平的作用。结论:本研究表明黄连及左金丸降低热性模型动物升高的胃肠激素水平的作用较好,左金丸及黄连治疗功能性胃肠疾病可能与其对胃肠激素水平的作用相关。关键词:左金丸反左金丸功能性胃肠疾病胃肠激素 The effectofZUoJINWAN andFANZUoJlNWAN on theinnuence ofgastrointestinal hormones secretiOn disease modeI 【Abstract】Objective: To study thefunction andthechange ofthegastrointeStinalhomones occur in the process offunctional gaStrointestinal disease(FGID).Compare the dif-ference ofthe ef诧cte of Zuoiinwan andFanzuojinwan and :use SD rats,radixaconiti,cinnamon,rhizoma zingiberis,fmctus“gus仃i lucidiwith proportion of1:l:1:l,made into2g/m water decoction,filling stomach eVe叮day,with dose of 0g/l( sixweeks tomakethemal gaStrointestinal diseases model,take thedifrerent drugs pare gaStrointestinal ho啪ones :The STT(SS) and gallbladder contraction K)of model animal were found signi6cantly higher,rhizoma coptidis can dramatically reduce theSS K levelrise,ZUOJINWAN can significantly reduce the K,but theFANZUOJINWAN and WuZhuYu cannot been ObserVed reduce theSS and increase :This study shows thatthefunction ofco