于春艳 【摘要】 目的：探讨血生化指标和纤维化指标在肝硬化患者中的表达价值及临床意义。方法：选取2019年6-12月本院收治的肝硬化患者300例作为研究组，同时选取相同时间段健康体检的人群 300例作为对照组，两组均进行血生化指标和纤维化指标检验。比较两组血生化指标（ADA、AFU、LAP、GLDH、TBIL、ALP、AST、TBA）和纤维化指标（PCⅢ、HA、LN、Ⅳ-C），以及Ⅳ-C、LN、HA、AFP、AFU单独检测和五项联合检测诊断肝硬化的阳性率。结果：研究组PCⅢ、HA、LN、Ⅳ-C、ADA、AFU、LAP、GLDH、TBIL、ALP、AST、TBA均高于对照组，PAB、CHE均低于对照组，差异均有统计学意义（P<）。血清Ⅳ-C、LN、HA、AFP、%、%、%、%、%;%;五项指标联合检测的阳性率高于各指标单独检测（P<）。结论：在肝硬化患者中，血生化指标以及纤维化指标检验具有一定的诊断价值，临床上应当进一步推广应用。 【关键词】 血生化指标 纤维化指标 肝硬化 Study on the Expression Value and Clinical Significance of Blood Biochemical Indexes and Fibrosis Indexes in Patients with Liver Cirrhosis/YU Chunyan. //Medical Innovation of China， 2021， 18（14）： -163 [Abstract] Objective： To explore the expression value and clinical significance of blood biochemical indexes and fibrosis indexes in patients with cirrhosis. Method： A total of 300 liver cirrhosis patients admitted to our hospital from June to December 2019 were selected as the study group， and 300 healthy people in the same period of time were selected as the control group， blood biochemical indexes and fibrosis indexes were tested in both groups. Blood b iochemical indexes （ADA， AFU， LAP， GLDH， TBIL， ALP， AST， TBA） and fibrosis indexes （PCⅢ， HA， LN， Ⅳ-C） were compared between the two groups， and the positive rate of the diagnosis of cirrhosis were compared between the two groups. Result： PCⅢ， HA， LN， Ⅳ-C， ADA， AFU， LAP， GLDH， TBIL， ALP， AST and TBA in the study group were all higher than those in the control group， while PAB and CHE were lower than those in the control group， the differences were statistically significant （P [Key words] Blood biochemical index Fibrosis index Liver cirrhosis First-authors address： Chinese Medicine Hospital of Jiamusi， Jiamusi 154002， China. doi：.1674- 肝硬化屬于慢性进行性的肝脏纤维化病变，这种疾病发生后不容易治愈，与此同时肝功能也会发生损伤。随着患者病情的不断发展，损伤情况也会逐渐加重，甚至还会出现癌变，威胁患者的生命[1]。诊断和针对性的治疗
