复方片仔癀肝宝对乙醇代谢的影响.docx

复方片仔癀肝宝对乙醇代谢的影响*
林珊1,2 陈达鑫1,2 赵锦燕1,2 曾建伟1,2 洪振丰1,2#
（1福建中医药大学中西医结合研究院 福州350122；2福建省中西医结合老年性疾病重点实验室 福州350122）
摘要：目的：探讨复方片仔癀肝宝对乙醇代谢的影响。方法：SD雄性大鼠随机分为正常对照组、模型组、海王金樽组（阳性对照）和复方片仔癀肝宝高、中、低剂量组，每组8只。 h除了正常对照组，其余各组灌胃白酒。采用顶空气质联用法（HS-GC-MS）、1、2、3、5 h大鼠血液中的乙醇浓度，运用ELISA法检测乙醇达到峰值时乙醇脱氢酶和乙醛脱氢酶的含量。结果：复方片仔癀肝宝组在不同时间点大鼠血液中的乙醇、乙醇脱氢酶和乙醛脱氢酶的浓度均低于模型组（P＜）。结论：复方片仔癀肝宝促进乙醇代谢，达到解酒的目的。
关键词：复方片仔癀肝宝；乙醇代谢；顶空气质联用仪
Effects of Complex Prescription Pianzaihuang Ganbao on Alcohol Metabolism
LIN Shan1,2, CHEN Da-xin1,2, ZHAO Jin-yan1,2, ZENG Jian-wei1,2, HONG Zhen-feng1,2#
(1The Institute of Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou350122; 2Fujian Provincial Laboratory of Integrated Traditional Chinese and Western Medicine, Fuzhou350122)
Abstract: Objective: To observed the anti-alcoholism effect of complex prescription Pianzaihuang Ganbao (GB). Methods: Male SD rats were divided into six groups randomly as follows: control group, model group, GB low dose group, GB middle dose group, GB high dose group and Haiwangjinzun group (HWJZ, as positive control). After oral medication, the rats were orally administration with alcohol, except for the rats in the control group. Blood was collected after , 1, 2, 3, 5 hours drinking alcohol separately. The content of alcohol in blood were determined by HS-GC-MS, the content of