doi:.1003- ·论著· gafur monotherapy neoadjuvant chemotherapy in patients with advanced gastric cancer before surgery and its influence on the levels of matrix metalloproteinase-9 and vascular endothelial growth factor. CHEN Yi, CAO Qiang, YANG Jia-yuan, GAO Cheng-dong, ZHUO Fei. Department of General Surgery, Xi’ an Changan District Hospital, Xi'an 710100, Shaanxi, CHINA 【Abstract】 Objective To observe the effect of capecitabine combined with oxaliplatin (CAPEOX), tegafur combined with oxaliplatin (SOX), and tegafur monotherapy neoadjuvant chemotherapy regimen in preoperative treat- ment of advanced gastric cancer, and to analyze its effects on the levels of matrix metalloproteinase-9 (MMP-9) and vas- cular endothelial growth factor (VEGF). Methods A total of 150 patients with advanced gastric cancer who planned to undergo gastric cancer surgery in Xi'an Chang'an District Hospital from January 2018 to December 2019 were selected as the research subjects. According to random number table method, the patients were randomly divided into CapeOX group, SOX group, and tegafur monotherapy group, with 50 cases in each group. A total of 8 cycles of chemotherapy were perf
